某氡温泉周边居民外周血淋巴细胞微核的变化

Change of micronucleus in peripheral blood lymphocytes of the residents surrounding hot springs with radon

目的 观察氡温泉周边居民外周血淋巴细胞微核率,为氡温泉对健康是否有影响提供依据.方法 采用简单随机抽样法抽取某地氡温泉周边居民42人;同时简单随机抽取生活习惯相似,但未接触过氡温泉的居民44人.采用胞质分裂阻断微核法检测两组居民外周血淋巴细胞微核.结果 氡温泉组的微核率（u=8.26,P＜0.01）和微核细胞率（x2=47.76,P＜0.01）均值显著高于对照组.氡温泉组微核率和微核细胞率随着年龄的增加而增加,且差异具有统计学意义（x2=44.034、27.739,P＜0.01）.氡温泉组女性的微核率（u=7.98,P＜0.01）和微核细胞率（x=37.123,P＜0.01）均高于男性且差异具有统计学意义.控制年龄、性别、吸烟和饮酒等混杂因素后,氡暴露与微核率呈高度正相关（x2=57.68,P＜0.01）.结论 高氡温泉能够引起居民外周血淋巴细胞微核率增加.

Objective To provide the basis for radon spring if there are any adverse effects that radon spring might have on human health by detecting micronucleus rate in peripheral blood lymphocytes of the residents surrounding with radon hot springs.Methods Two groups were drew at simple random.Radon group had 42 residents surrounding with radon hot springs and control group had 44 residents with same living habit without radon hot springs.Cytokinesis-block micronucleus method was used to measure micronucleus in two groups.Results In radon group the averages of micronucleus rate（u=8.26, P〈0.01） and micronucleus cell frequency（x2=47.76, P〈0.01） were significantly higher than control group.In radon group, the micronucleus rate and micronucleus cell frequency were significantly increased with age （x2=44.034, 27.739, both P〈0.01）;and the micronucleus rate（u=7.98, P〈0.01） and micronucleus cell frequency （x2=37.123, P〈0.01） of female were significantly higher than male.The micronucleus rate was associated with radon exposure （x2=57.68, P〈 0.01） controlling of confounding factors such as age, gender, smoking and drinking alcohol.Conclusions High radon springs could cause the increase of the incidence of micronucleus in peripheral blood lymphocyte.