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克服单倍体相合造血干细胞移植免疫屏障的策略

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摘要 异基因造血干细胞移植(allo-HSCT)是恶性血液病的有效治疗手段,供者来源困难一直限制了此项技术的广泛应用。单倍体相合造血干细胞移植(haplo-HSCT)使3/6相合亲属移植成为可能,其中3/6相合亲属可来源于父母、同胞、堂兄妹、表亲之一,几乎能为100%的人群找到供者,有望从根本上解决供者来源问题。haplo-HSCT还具有易于取得干细胞以及今后有可能再次采集供者干细胞进行细胞治疗等优点,从而引起人们的广泛关注。
作者 何祎 韩明哲
出处 《实用器官移植电子杂志》 2015年第5期278-281,共4页 Practical Journal of Organ Transplantation(Electronic Version)
基金 国家高技术研究发展计划(863)项目(2013AA020103)
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