胸部肿瘤患者调强放疗后动态心电图变化的临床对比研究

Clinical comparative study of breast cancer patients after IMRT Holter changes

目的:探讨胸部肿瘤患者在不同时间段、不同类型肿瘤、不同治疗方法下调强放疗动态心电图变化情况。方法:选取2010年4月-2013年4月95例胸部肿瘤患者为研究对象,按照肿瘤类型分成肺癌组35例,乳腺癌组29例,食管癌组31例;按照治疗方法分成单纯放疗组26例,同步放化组34例,序贯放化组35例,分别在治疗前、治疗后和治疗结束6个月后观察动态心电图变化情况。结果:治疗后和治疗前在偶发室(房)性心律失常、ST-T段改变动态心电图异常发生率上比较差异有统计学意义(P<0.05),而治疗结束6个月后和治疗前在偶发室(房)性心律失常、ST-T段改变动态心电图异常发生率比较差异无统计学意义(P>0.05)。不同治疗方法和不同肿瘤类型上治疗前动态心电图各项指标比较差异无统计学意义(P>0.05);治疗后各项指标比较差异也无统计学意义(P>0.05)。结论:调强放射治疗后胸部肿瘤患者动态心电图改变多在早期出现,且为可逆性。调强放射治疗精确性保证了不同类型胸部肿瘤放疗后动态心电图改变无显著差异性。

Objective： To investigate breast cancer patients at different time periods,different types of cancer,different treatments of radiotherapy Holter strong downward changes. Methods： All 95 breast cancer patients according to tumor type were 35 cases of lung cancer,breast cancer group,29 cases,31 cases of esophageal cancer. Divided into groups according to treatment with radiotherapy alone 26,synchronous chemoradiotherapy group 34 cases,35 cases of sequential chemoradiotherapy group. Before and after treatment and six months after the end of treatment was observed on dynamic ECG changes. Results： Before treatment,and treatment in occasional room（ room） arrhythmia,incidence of abnormalities ST-T segment changes on Holter difference was statistically significant（ P 0. 05）,but before and after treatment in episodic treatment room（ room） arrhythmia,ST-T segment changes in the incidence of abnormal Holter was no significant difference（ P 0. 05）. The former Holter indexes difference was not statistically significant（ P 0. 05） after treatment in different treatment methods and different tumor types. Each index difference also was not statistically significant after treatment（ P 0. 05）. Conclusion： IMRT breast cancer patients after treatment Holter change much in the early stage,and is reversible. IMRT guarantee the accuracy of the different types of breast cancer radiotherapy after changing Holter no significant difference.