肾癌术后干扰素治疗对人体免疫功能的影响

Immune function after interferon treatment in post-surgery patients with renal cell carcinoma

目的:评价肾癌患者术后应用干扰素免疫治疗对机体免疫水平的影响。方法:选取肾癌患者50例,术后应用干扰素(IFN)行免疫治疗,同时选取术后未行免疫治疗的肾癌患者45例作为对照组。于术前及术后1、2、3个月检测患者免疫指标(CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD16+56+),比较两组间指标差异及手术前后免疫指标变化情况。结果:术前免疫治疗组与对照组间各项免疫指标差异无统计学意义(P>0.05)。术后1、2、3个月对照组各免疫指标与术前相比差异无统计学意义(P均>0.05),治疗组术后第2、3个月较术前均有显著差异(P<0.05、P<0.01)。结论:肾癌术后应用干扰素免疫治疗能有效提高机体免疫水平,对患者远期预后需进一步随访。

Objective： To evaluate the change of immune function in postoperative patients with renal cell carcinoma treated with interferon. Methods： Fifty patients with renal cell carcinoma treated with interferon after operation consisted of the treatment group. The control group included 45 patients without any treatment after operation. Immune parameters,including CD3＋,CD4＋,CD8＋,CD4＋/ CD8＋,CD19＋and CD16＋56＋were determined before and at the1 th,2nd,3th month after therapy. Results： The levels of detected immune parameters had no statistic difference before operation（ P 0. 05） between the two groups. In control group,the levels of immune parameters had no statistic difference at the 1th,2nd,3th month after operation（ P 0. 05）. However,statistic difference was found in treatment group at the 2nd and 3th month after operation（ P 0. 05,P 0. 01）. Conclusion： Interferon can increase the immune level of patients with renal cell carcinoma after operation,and its influence on the long-term survival needs further study.