^(89)SrCl_2与^(99)Tc-MDP联合治疗转移性骨肿瘤的临床研究

Clinical effect of combination of ^(89)SrCl_2 and ^(99)Tc-MDP in the treatment of metastatic bone tumor

目的:评价氯化锶(89SrCl2)与99锝-二甲基二磷酸盐(99Tc-MDP)联合治疗转移性骨肿瘤的临床疗效及不良反应发生情况。方法:将转移性骨肿瘤患者126名随机分为89Sr Cl2联合99Tc-MDP治疗组及89Sr Cl2单项治疗组进行治疗,比较两组疼痛反应情况、骨转移灶的治疗情况以及不良反应的发生率。结果:对于转移性骨肿瘤的镇痛效果,联合治疗组患者中,有效率为23.81%,显效率61.90%,无效率14.29%;单项治疗组患者有效率为12.70%,显效率58.73%,无效率28.57%,两组患者镇痛疗效的差异具有统计学意义(P<0.01)。对于转移性骨肿瘤骨转移灶的治疗效果和不良反应发生率,联合治疗组患者中和单项治疗组患者的差异无统计学意义(P>0.05)。结论:氯化锶(89SrCl2)与99锝-二甲基二磷酸盐(99Tc-MDP)联合治疗转移性骨肿瘤疼痛具有明显的效果,也可消退部分转移病灶,不良反应发生率较低,临床效果优于89SrCl2单项治疗效果。

Objective： To assess the clinical effect and adverse effect of combination of 89SrCl2 and 99Tc-MDP in treatment of metastatic bone tumor. Methods： A total of 126 patients were randomly divided into combination treatment group treated with 89SrCl2 and 99Tc-MDP and single treatment group treated with89 Sr Cl2. The pain,treatment efficacy and adverse effect of metastatic bone tumor were compared between the two groups. Results： The effective rate of combination treatment group was 23. 81%. The recovery rate was 61. 90% and ineffective rate was 14. 29%. The effective rate,recovery rate and ineffective rate of single treatment group were 12. 70%,58. 73% and 28. 57% respectively. Significant difference was found between the two groups（ P 0. 01）. For treatment efficacy and adverse effect,there was no significant difference between the combination treatment group and single treatment group（ P 0. 05）.Conclusion：89Sr Cl2and99Tc-MDP had significant effect on controlling pain,eliminating metastatic lesion and decreasing the adverse effect,which was better than the efficacy of89 Sr Cl2treatment.