摘要
目的:评价氯化锶(89SrCl2)与99锝-二甲基二磷酸盐(99Tc-MDP)联合治疗转移性骨肿瘤的临床疗效及不良反应发生情况。方法:将转移性骨肿瘤患者126名随机分为89Sr Cl2联合99Tc-MDP治疗组及89Sr Cl2单项治疗组进行治疗,比较两组疼痛反应情况、骨转移灶的治疗情况以及不良反应的发生率。结果:对于转移性骨肿瘤的镇痛效果,联合治疗组患者中,有效率为23.81%,显效率61.90%,无效率14.29%;单项治疗组患者有效率为12.70%,显效率58.73%,无效率28.57%,两组患者镇痛疗效的差异具有统计学意义(P<0.01)。对于转移性骨肿瘤骨转移灶的治疗效果和不良反应发生率,联合治疗组患者中和单项治疗组患者的差异无统计学意义(P>0.05)。结论:氯化锶(89SrCl2)与99锝-二甲基二磷酸盐(99Tc-MDP)联合治疗转移性骨肿瘤疼痛具有明显的效果,也可消退部分转移病灶,不良反应发生率较低,临床效果优于89SrCl2单项治疗效果。
Objective: To assess the clinical effect and adverse effect of combination of 89SrCl2 and 99Tc-MDP in treatment of metastatic bone tumor. Methods: A total of 126 patients were randomly divided into combination treatment group treated with 89SrCl2 and 99Tc-MDP and single treatment group treated with89 Sr Cl2. The pain,treatment efficacy and adverse effect of metastatic bone tumor were compared between the two groups. Results: The effective rate of combination treatment group was 23. 81%. The recovery rate was 61. 90% and ineffective rate was 14. 29%. The effective rate,recovery rate and ineffective rate of single treatment group were 12. 70%,58. 73% and 28. 57% respectively. Significant difference was found between the two groups( P 0. 01). For treatment efficacy and adverse effect,there was no significant difference between the combination treatment group and single treatment group( P 0. 05).Conclusion:89Sr Cl2and99Tc-MDP had significant effect on controlling pain,eliminating metastatic lesion and decreasing the adverse effect,which was better than the efficacy of89 Sr Cl2treatment.
出处
《现代肿瘤医学》
CAS
2015年第22期3333-3335,共3页
Journal of Modern Oncology
基金
广东省自然科学基金项目(编号:10451018201004365)