p16基因与口腔颌面肿瘤

p16 gene and oral malignant tumors

p16基因是近年发现的一种多肿瘤抑制基因,主要通过抑制细胞周期素依赖性蛋白激酶CDK4的活性,阻止细胞从G1进入S期,直接参与细胞周期的调控。p16基因失活原因多样,与多种肿瘤的发生发展密切相关。明确p16基因与口腔恶性肿瘤的关系对口腔恶性肿瘤的诊断、治疗和预后等方面都有重要意义。

p16 gene is found in recent years,as a kind of tumor suppressor genes,mainly by inhibiting cell cycle dependent protein kinase activity of CDK4 to prevent cells from G1 to S phase,and directly involved in cell cycle regulation. p16 gene inactivation reasons are diverse. p16 gene is closely related to a variety of tumor development. The relationship between p16 gene and oral malignant tumor has important significance in diagnosis,treatment and prognosis of oral malignant tumor.