复方康复灵对体部伽玛刀治疗非小细胞肺癌引起的急性放射反应的防护作用

Protective effect of compound Kangfuling on body gamma knife in treating acute radiation reaction of nonsmall cell lung cancer

目的探讨复方康复灵对体部伽玛刀治疗非小细胞肺癌急性放射反应的防护作用。方法选取接受体部伽玛刀治疗的非小细胞肺癌患者107例,随机分为观察组(55例)和对照组(52例)。观察组在放疗开始后给予复方康复灵口服,疗程1个月,比较两组的急性放射反应。结果治疗后观察组患者外周血白细胞下降发生率为5.5%,对照组为21.2%(P<0.05);观察组急性放射性肺炎发生率为16.4%,对照组为15.4%(P>0.05);观察组急性放射性食管炎发生率为25.5%,对照组为28.8%(P>0.05)。结论复方康复灵对非小细胞肺癌患者接受体部伽玛刀治疗引起的外周血白细胞下降具有较好的预防作用,值得临床推广。

Objective To investigate the protective effect of compound Kangfulin on acute radiation reaction of the body gamma knife in treatment of non-small cell lung cancer. Methods To select 107 patients who received the body gamma knife treatment of non-small cell lung cancer,then divided them into observation group（ 55 cases） and control group（ 52 cases） randomly. The observation group was given the compound Kangfulin for a month after the beginning of radiotherapy,and compared the acute radio injury between two groups. Results The decreasing incidence of peripheral blood leukocytes in observation group was 5. 5% and control group was 21. 2%. The difference was statistically significant（ P〈0. 05）. The incidence of acute radiation pneumonitis in observation group was 16. 4% and control group was 15. 4%. The difference was not statistically significant（ P〉0. 05）. The incidence of acute radiation esophagitis in observation group was 25. 5% and control group was 28. 8%. The difference was not statistically significant（ P〉0. 05）. Conclusion The compound kangfulin has a good preventive effect on the decreasing Peripheral blood leukocytes of the nonsmall cell lung cancer patients who have received body gamma knife treatment. It was worthy of promotion in clinic.