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慢性粒细胞白血病靶向治疗相关基因及信号通路 被引量：2

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摘要 慢性粒细胞白血病（CML）是起源于骨髓多能造血干细胞的恶性增殖性疾病,Ph染色体t（9;22）（q34;q11）是其特征性细胞遗传学标志。Ph染色体形成的bcr/abl融合基因编码具有较强酪氨酸激酶活性的蛋白BCR/ABL,通过改变关键的调节蛋白磷酸化状况来影响多种信号传导途径,引起细胞周期紊乱、增殖失控或凋亡受阻,从而导致白血病的发生。
作者 董菲 孙成铭
机构地区 青岛大学 青岛大学医学院附属烟台毓璜顶医院
出处 《检验医学与临床》 CAS 2015年第20期3116-3119,共4页 Laboratory Medicine and Clinic
基金 山东省优秀中青年科学家科研奖励基金(BS2011YY064)
关键词 慢性粒细胞白血病 基因 信号通路 靶向治疗 白血病干细胞
分类号 R733.72 [医药卫生—肿瘤]
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参考文献43

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二级参考文献37

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检验医学与临床
2015年 第20期

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