滑膜间充质干细胞关节腔内注射治疗关节软骨损伤

Intra-articular injection of synovial mesenchymal stem cells to treat articular cartilage injury

背景:研究显示,在众多的种子细胞中滑膜间充质干细胞对关节软骨损伤再生修复具有许多独特的优势。目的:对滑膜间充质干细胞的研究进展及其关节腔内注射治疗关节软骨损伤的应用进行综述。方法:第一作者通过计算机检索Pub Med和CNKI数据库2004年1月至2014年12月的相关文献,检索关键词为"滑膜间充质干细胞、注射治疗、软骨修复;Synovial mesenchymal stem cells;Intra-articular injection;Cartilage repair",纳入57篇文献进行分析。结果与结论:滑膜间充质干细胞分离培养方法简便,在软骨损伤修复方面具有很大的优势,通过将其注射于关节腔内治疗关节软骨损伤具有一定的可行性和安全性,作为一种潜在的治疗方式,有望给软骨损伤患者带来曙光,但仍然存在诸多问题,还需要进一步深入研究。

BACKGROUND： Among various seed cells, synovial mesenchymal stem cells have unique advantages in the repair of articular cartilage injury. OBJECTIVE： To review the progress of synovial mesenchymal stem cells and its intra-articular injection in the treatment of articular cartilage injury. METHODS： The first author searched Pub Med and CNKI by computer to retrieve articles published from January 2004 to December 2004 using the keywords of ＂synovial mesenchymal stem cells; intra-articular injection; cartilage repair＂ in English and Chinese, respectively. Finally, 57 articles were included in result analysis. RESULTS AND CONCLUSION： It is easy to isolate and culture synovial mesenchymal stem cells, which has great advantages in cartilage repair. What＇s more, intra-articular injection therapy for articular cartilage injury is feasible and safe. Intra-articular injection of synovial mesenchymal stem cells is a very promising treatment for cartilage damage, but there are still many problems to be solved in the future.