微管相关蛋白2:调节神经元发育、结构稳定及突起形成和突触可塑性

Microtubule-associated protein-2:regulating neuronal development,structural stability,projection formation and synaptic plasticity

背景:微管相关蛋白2是一种调节微管蛋白组成的重要调节因子,为微管相关蛋白的主要成员之一,在神经系统的发生及功能的维持上起着重要的作用,研究发现微管相关蛋白2能够促进神经损伤的修复与重建。目的:探讨总结微管相关蛋白2与神经损伤的关系及发挥作用的机制。方法:由第一作者运用计算机检索系统检索自1976年1月至2015年1月所有发表的与微管相关蛋白2的相关的文献,以"microtubule-associated protein-2(MAP-2),nerve injury,progress"为检索词在同一领域选择近期发表或发表在权威杂志上的文章。排除重复性的文献及时间跨度比较长的文献,从检索结果中共选择了82篇文章进一步的分析。结果与结论:微管相关蛋白2主要存在于中枢神经系统神经元胞体和树突中。微管相关蛋白2参与神经损伤的修复过程,对神经元形态学和可塑性方面其促进作用。在神经损伤早期提升微管相关蛋白2的浓度可早期恢复神经元的功能。

BACKGROUND;Microtubule-associated protein-2 is a kind of important regulatory factor in regulating tubulin assembly.As one of the main members of microtubule-associated proteins,microtubule-associated protein-2 plays an important role in the repairing and development of the nervous system function.It has been found that microtubule-associated protein-2 can promote the repair and rebuilding of injured nerves.OBJECTIVE;To summarize the relationship between microtubule-associated protein-2 and nerve injury as well as the mechanism of action.METHODS;The Pub Med database and CNKI database were retrieved by the fist author for the articles related to microtubule-associated protein-2 published from January 1976 to January 2015.The key words were ＂microtubule-associated protein-2（MAP-2）,nerve injury,progress＂ in English and Chinese,respectively.In the same field,articles published recently or in authorized journals were preferred.Repetitive or old articles were excluded,and finally 82 articles were included in result analysis.RESULTS AND CONCLUSION;Microtubule-associated protein-2 is involved in nerve repair,and plays a promoting role in neuronal morphology and plasticity.To increase the concentration of microtubule-associated protein-2 contributes to the recovery of neurologic function in the early stage after nerve injury.