QIMT及QAS技术评价颈总动脉粥样硬化与左心功能相关性

Correlation Between Carotid Atherosclerosis and Left Ventricular Function Evaluated by QIMT and QAS Technique

目的探讨颈总动脉粥样硬化疾病患者颈总动脉硬化程度与左心功能的相关性。方法应用QIMT和QAS技术对CAS患者75例与健康人群50例自动测量颈总动脉的内中膜厚度(IMT)、血管扩张性系数(DC)、血管顺应性系数(CC)、僵硬度参数(β)和脉搏波传导速度(PWV)。应用超声心动图测量室间隔舒张末期厚度(IVSd)、左室舒张末期内径(LVDd)、左室质量(LVM)、射血分数(EF)、E/A、E/E'。对比所测量结果并进行相关分析。结果 CAS患者颈总动脉IMT、β、PWV显著高于健康人群,DC、CC显著低于健康人群;CAS患者IVSd、LVM、E/E'显著高于健康人群;差异均具有统计学意义(P<0.05)。CAS患者IMT、PWV及β与CC呈负相关,与E/E'呈正相关。结论 CAS患者动脉僵硬度增高,同时伴有左室舒张功能受损,二者之间呈正相关性。

Objective To evaluate the correlation between the degree of arteriosclerosis and left ventricular function in patients with carotid atherosclerosis （CAS）. Methods The intima-media thickness （IMT）, vessel distensibility coefficient （DC）, vessel compliance coefficient （CC）, stiffnessβand pulse wave velocity （PWV） of 75 CAS patients and 50 healthy subjects were measured by QIMT and QAS. The IVSd, LVDd, LVM, EF, E/A and E/E＇ were measured by echocardiography. The measuring results of two groups were compared and analyzed. Results The IMT,β, PWV, IVSd, LVM and E/E＇ of CAS patients were significantly higher than those of healthy subjects, the DC and CC were significantly lower than those of healthy subjects, with statistical difference （P〈0.05）. The IMT, PWV andβof CAS patients had negative correlation with CC, and had positive correlation with E/E＇. Conclusions CAS patients have high artery stiffness, and impaired left ventricular function. There results show positive correlation between CAS and left ventricular dysfunction.