血清β人绒毛膜促性腺激素与孕早期血脂对预测妊娠高血压疾病的价值

Value of Serum β Human Chorionic Gonadotropin and Blood Lipid in Early Pregnancy in Predicting Pregnancy-induced Hypertension Disease

目的：探讨血清β人绒毛膜促性腺激素（β-HCG）与孕早期血脂对预测妊娠高血压疾病的价值。方法选取2011年1月至2014年1月入住我院的妊娠高血压产妇150例，设为妊娠高血压组，另选取同期入住我院的正常健康产妇150例为正常对照组。比较两组孕妇一般性资料、孕早期（37~60天）血脂水平以及妊娠中期血清β-HCG水平，分析孕妇并发妊娠高血压的危险因素。结果妊高组患者的β-HCG、甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白水平均明显高于正常组，差异具有统计学意义（P＜0.05）。 Logistic回归分析显示，甘油三酯（OR =2.561）、高密度脂蛋白（OR =2.023）、β-HCG （OR =1.347）和低密度脂蛋白（OR =1.248）均是导致妊娠高血压的危险因素。结论血清β人绒毛膜促性腺激素与孕早期血脂均是导致妊娠高血压的危险因素，可以作为妊高症诊断的临床参考。

Objective To explore the value of serumβhuman chorionic gonadotropin （β-HCG） and blood lipid in early pregnancy in predicting pregnancy-induced hypertension disease. Methods 150 cases of pregnant women with pregnancy-induced hypertension disease admitted to our hospital from January 2011 to January 2014 were selected as gestational hypertension group, 150 cases of healthy pregnant women admitted to our hospital in same period were set as normal group. The general information, levels of blood lipid in early pregnancy （37 ~ 60 d） and serum β-HCG level in second trimester of pregnancy were compared between two groups, the risk factors of pregnancy-induced hypertension was analyzed. Results The levels ofβ-HCG, triglyceride, cholesterol, high-density lipoprotein, low density lipoprotein in gestational hypertension group were significantly higher than those in control group, with statistical difference （P〈0.05）. The analysis of Logistic regression showed that triglyceride （OR =2.561）, high-density lipoprotein （OR =2.023）,β-HCG （OR =1.347） and low density lipoprotein （OR=1.248） were the risk factors for pregnancy-induced hypertension. Conclusions The serumβ-HCG and blood lipid in early pregnancy are the risk factors for pregnancy-induced hypertension, which can serve as the clinical reference for the diagnosis of pregnancy-induced hypertension.