透析加灌流在治疗高血压、皮肤瘙痒等方面的疗效观察

Effect Observation on Hemodialysis Combined with Hemoperfusion in Treatment of Hypertension, Pruritus and Other Aspects

目的观察分析透析加灌流在治疗顽固性高血压、皮肤瘙痒及减低PTH方面的临床疗效。方法选取2014年2月至2015年2月在我院接受血液透析-灌流联合治疗的尿毒症患者60例作为研究对象。比较患者治疗前后的血压(收缩压和舒张压)、PTH水平和皮肤瘙痒的实验室检查结果 (包括BUN、Cr、Ca),评估透析和灌流联合疗法的临床疗效。结果患者治疗后收缩压和舒张压均显著优于治疗前,差异具有统计学意义(P<0.05),血压治疗总有效率为96.67%。患者治疗后PTH水平和皮肤瘙痒的实验室检查结果均显著改善,差异具有统计学意义(P<0.05),皮肤瘙痒治疗总有效率为95.0%。结论透析加灌流在治疗顽固性高血压、皮肤瘙痒及减低PTH等方面具有显著的临床疗效,可提高患者生活质量,值得在临床推广与应用。

Objective To observe and analyze the clinical effect of hemodialysis （HD） combined with hemoperfusion （HP） in treating refractory hypertension, pruritus and in reducing PTH level. Methods 60 cases of uremic patients treated with hemodialysis combined with hemoperfusion in our hospital from February 2014 to February 2015 were selected as research objects. The blood pressure （systolic pressure and diastolic pressure）, PTH level and laboratory results of pruritus （including BUN, Cr, Ca） before and after treatment were compared, the clinical effect of hemodialysis combined with hemoperfusion was evaluated. Results The systolic pressure and diastolic pressure of patients after treatment were significantly better than those before treatment, with statistical difference （P 〈0.05）, and the total effective rate of hypertensive therapy was 96.67%. The PTH level and laboratory results of pruritus of patients after treatment were significantly improved （P〈0.05）, and the total effective rate was 95.0%. Conclusions Hemodialysis combined with hemoperfusion has significant clinical effect in treating refractory hypertension, pruritus and in reducing PTH, which can improve the patients＇ life quality and deserve clinical promotion and application.