CD8^+T细胞在乙型肝炎病毒感染发病中的作用研究进展

Role of CD8+T cells in the pathogenesis of hepatitis B virus infection

在乙型肝炎病毒(HBV)感染过程中,HBV特异性CD8^+T细胞的作用至关重要,它不仅参与病毒的控制和清除,同时也参与疾病的发病,机体的免疫应答水平是决定HBV被清除还是在体内长期存在的关键。本文主要讨论了在HBV感染的急性期和慢性期,HBV特异性CD8^+T细胞的表型和功能变化的相关最新研究进展,总结了关于CD8^+T细胞基础研究的最新知识,介绍了HBV感染的不同时期CD8^+T细胞对病毒清除或病毒持续存在的作用机制。同时,也对新型的HBV特异性CD8^+T细胞细胞免疫模型系统和检测方法的建立做了介绍,并列举了与传统方法无法比拟的检测优势和深远意义。

Hepatitis B virus （HBV） specific CD8q＇ cells play a crucial role in the pathogenesis of HBV infection. It is not only involved in the HBV inhibition and clearance,but also in the progress of the illness. Immune response is the key fac- tor that determines whether HBV infection is gone or remained. This paper mainly discussed the latest research progress related to the phenotypes and functions of HBV specific CD8＋T cells in the acute phase and chronic phase of HBV infection, and summarized updates on basic research of CD8＋T cells,aiming at providing a further understanding of what roles CD8＋T cells play in virus clearance at different stages of HBV infection. Meanwhile,we made an introduction of novel in vitro immune system model of HBV specific CD8＋T cells,as well as innovative techniques to detect HBV-specific CD8＇T cell,the advantage and sig- nificance of which is incomparable by any traditional methods.