热毒宁注射液不同稀释浓度治疗儿童急性上呼吸道感染的疗效与安全性观察

Efficacy and Safety of Different Concentration of Reduning Injection for Children with Acute Upper Respiratory Tract Infection

目的：考察热毒宁注射液不同稀释浓度治疗儿童急性上呼吸道感染的疗效与安全性。方法：采用回顾性调查分析的方法，对120例使用热毒宁注射液治疗的急性上呼吸道感染患儿，按热毒宁的不同稀释浓度（药液用量∶溶媒量）分为＞1∶4组（高浓度组）、1∶4～1∶20组（中浓度组）和＜1∶20组（低浓度组），观察3组患儿的疗效和安全性。结果与结论：高、中浓度两组患儿症状和体征恢复时间相当，但疗程均显著短于低浓度组（P＜0.05）；高、中浓度两组总有效率分别为94.59%和91.80%，差异无统计学意义（P＞0.05），但均显著高于低浓度组的63.64%（P＜0.05）；中、低浓度组不良反应发生率分别为4.92%和4.55%，差异无统计学意义（P＞0.05），但均显著低于高浓度组的16.22%（P＜0.05）。热毒宁注射液不同稀释浓度对治疗儿童急性上呼吸道感染的疗效和安全性均有影响，适当稀释（药液用量∶溶媒量为1∶4-1∶20）不仅具有良好的临床疗效，而且安全性也高。

Objective: To investigate the efficacy and safety of different concentration of Reduning injection for children with acute upper respiratory tract infection (AURTI). Methods: Retrospective analysis was used in the study, 120 children with AURTI who were treated by Reduning injections were grouped into three groups by different solutions concentrations of Reduning injections, that were the >1∶4 (liquid amount: solvent amount) group (High-concentration group), 1∶20-1∶4 group (Moderate-concentration group) and <1∶20 group (Low-concentration group). The efficacy and safety was observed. Results & Conclusion:Recovery time of signs and symptoms of High- and Moderate-concentration groups were roughly the same, but significantly shorter than that of Low-concentration group (P<0.05); Total effective rates of High- and Moderate-concentration groups were 94.59% and 91.80% respectively, the difference between the two groups was not statistically significant (P>0.05), but they were significantly higher than that of Low-concentration group (63.64%) (P<0.05); Incidence of adverse reactions of Moderate- and Low-concentration groups were 4.92% and 4.55% respectively, the difference between the two groups was not statistically significant (P>0.05), but they were significantly lower than that of High-concentration group (16.22%) (P<0.05). Different solutions concentrations of Reduning injections have some impact on the efficacy and safety for AURTI, appropriate dilution has not only good clinical efficacy, but also high safety.