摘要
As a new form of fluorescent carbon nanomaterials, carbon dots (CDs) have many advantages such as simplicity of synthesis, low biological toxicity, resistance to photobleaching, excellent in biocompatibility and easy to modify. As the most inorganic mineral of human hard tissues including bone and tooth, calcium phosphate (CaP) materials have high biocompatibility and good biodegradability. The hydroxyapatite (HA), a common type of calcium phosphate, has been widely used in drug delivery, removal of heavy metal ions, gene transfection and other biomedical fields. Herein, a novel method for preparation of fluorescent calcium phosphate/carbon dot ( CaP/ CD) hybrid composites was described. We first prepared CDs with a quantum yield of 51.5 % by carbonization of citric acid with polyethylenimine (PEI) in one step. Next, the fluorescent CaP/CD hybrid composites upon UV ex- citation were obtained in the presence of carboxymethyl cellulose (CMC) as a template and CD as a co-template. The as-prepared CaP/CD hybrid composites consisted of irregularly shaped nanorods with a length of 50 - 140 nm and a diameter of 10- 25 nm were characterized by transmitted electron microscopy (TEM). And the highly mag- nified TEM image of CaP/CD hybrid composites showed that tens of CDs in shape of nanodot indeed existed in the CaP/CD hybrid composites. More importantly, CDs enabled the CaP/CD hybrid composites to emit bright blue flu- orescence under UV irradiation. In addition, the result of X-ray powder diffraction (XRD) patterns indicated that the crystalline phase of CaP/CD hybrid composites were in good agreement with those of hexagonal HA (JCPDS Da- ta Card 09-0432). Moreover, it was found that the as-synthesized CaP/CD hybrid composites were potentially use- ful in detecting the concentration of Cu2+ and imaging the cell with nontoxic as potential fluorescent probes.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2015年第B11期3-3,共1页
Chinese Pharmacological Bulletin