Study on the anti-hypertensive effect of total flavonoids of Cydonia oblonga Mill. and its mechanism based on anti-inflammatory function

Aim To study the anti-hypertensive effect of total flavonoids of Cydonia oblonga Mill. in spontaneously hypertensive rats, then preliminarily investigate the mechanism of action based on anti-inflammatory function. Methods Total flavonoids of COM （COMF） were separated and purified by the optimal process, SHR were divid- ed into 6 groups as SHR control group （SHR）, captopril group （CAP, 25mg· kg^-1 · d^-1）, Eucommia ulmoides Oliver group （EUO, 30 mg · kg^-1· d^-1）, low （COMF-L, 40 mg · kg^-1· d^-1）, middle （COMF-M, 80 mg · kg^-1 · d^-1） and high dose （COMF-H, 160 mg · kg^-1· d ^-1） of COMF groups. 8 Wistar-Kyoto （WKY） rats were given distilled water instead as control. The drugs were given by intragastric administration for 16 weeks, then the levels of IL-1β, IL-6, IL-10, TNF-α and CRP in serum were tested. Results Compared with WKY group, the levels of IL-I~, IL-6, TNF-α and CRP were increased and IL-10 was decreased; Compared with SHR group, the levels of IL-1β, IL-6, TNF-α and CRP were decreased in COMF groups （P 〈0.01 or P 〈0.05） , while IL-10 was increased a little but without any significant difference （P 〈 0.05 ）. Conclusion Total flavonoids of Cydonia ob- longa Mill. showed the anti-hypertensive activity in spontaneously hypertensive rats and the mechanism was related to the function of anti-inflammatory.