Effect of gastric acid secretion for L-pantoprazole sodium in rats

Aim To observe the effect of L-pantoprazole sodium on gastric acid secretion in rats. Methods The rats single injection to the drug on tail after fasting but help water 48h, then threading the pyloric ligation at the junction of the pylorus and duodenum, and the animals were fasted and ban water 5h. We remove the total gastrec- tomy, gastric juice was collected and the amount of the volume, and the determination of total acidity、total acidity secretion^pH value. Results L-pantoprazole sodium and pan pantoprazole sodium can significantly reduce the to- tal acidity secretion volume （P 〈 0.05）, increased gastric pH （P 〈 0.01 ）. D-pantoprazole sodium on gastric acid secretion of gastric juice and total PH had no significant effect （ P 〉 0. 05 ）. Conclusion L-pantoprazole sodiumhas significant inhibition of gastric acid secretion, the mechanism of the treatment of peptic ulcer may be through inhibition of proton pump discharge acid effect, to play a role in the protection of gastric mucosa.