TP化疗方案联合参芪扶正注射液治疗晚期卵巢癌的临床观察

Clinical Observation on TP Chemotherapy Combined with ShenQi FuZheng Injection in Treating Advanced Ovarian Cancer

目的:观察紫杉醇类+铂类(TP)化疗方案联合参芪扶正注射液治疗晚期卵巢癌患者的临床疗效、不良反应。方法:将111例晚期卵巢癌患者随机分为治疗组(57例)和对照组(54例)。对照组单用TP方案化疗,治疗组在此基础上加用参芪扶正注射液。观察2组临床疗效、化不良反应及治疗前后患者生活质量的变化情况。结果:2组治疗后KPS评分改善情况比较差异具有统计学意义(P<0.05)。治疗组在改善患者神疲乏力、纳差、恶心呕吐、失眠等方面优于对照组,差异具有统计学意义(P<0.05)。治疗组骨髓抑制、恶心呕吐、肝脏损害、肾脏损害、心脏毒性等不良反应发生率低于对照组,2组比较差异具有统计学意义(P<0.05)。总有效率治疗组为87.82%,对照组为57.41%,2组比较差异具有统计学意义(P<0.05)。复发率治疗组为12.28%,对照组为29.63%,2组比较差异有统计学意义(P<0.05)。1年生存率对照组为19.30%;治疗组为25.93%,治疗组略高于对照组,但差异无统计学意义(P>0.05)。结论:TP化疗方案联合参芪扶正注射液治疗晚期卵巢癌疗效确切,可降低化疗的毒副反应,改善临床症状。

Objective： To observe clinical effects and adverse drug reaction（ADR） of TP chemotherapy and Shen Qi Fu Zheng injection in the treatment for advanced ovarian cancer. Methods： All 120 patients were randomized into the treatment group and the control group, 60 cases each group, the control group accepted TP chemotherapy;while the treatment group Shen Qi Fu Zheng injection on the foundation of TP chemotherapy. Clinical effects, adverse reaction of the chemotherapy and life quality before and after treating were observed in both groups. Results： There was significant difference in the improvements of KPS scores after treating between both groups（P〈0.05）. The treatment group was better than the control group in improving exhaustion, poor appetite, nausea, vomiting and insomnia,the difference demonstrated statistical meaning（P〈0.05）. The treatment group was lower than the control group in the incidences of ADR including arrest of bone marrow, nausea and vomiting, liver damage, renal damage, heart toxicity and others, the difference showed statistical meaning（P〈0.05）. Total effective rate of the treatment group was 87.82%higher than 57.41% of the control group, the difference indicated statistical meaning（P〈0.05）. Relapse rate of the treatment group was 12.28%; lower than 29.63% of the control group, the difference presented statistical meaning（P〈0.05）. One-year survival rate of the control group was 19.30%, lower than 25.93% of the treatment group, while the difference had no statistical meaning（P〉0.05）. Conclusion： TP chemotherapy and Shen Qi Fu Zheng injection could obtain definite effects in the treatment for advanced ovarian cancer, it could reduce toxicity and adverse reaction of chemotherapy, and improve clinical symptoms.