血必净注射液联合清胰汤治疗重症急性胰腺炎40例

XueBiJing Injection Jointed with QingYiTang in Treating 40 Cases of Severe Acute Pancreatitis

目的:观察血必净注射液联合清胰汤治疗重症急性胰腺炎的临床疗效。方法:将80例患者随机分为观察组、对照组各40例,对照组给予抗休克治疗,抑制胰腺分泌,禁食水、胃肠减压,使用质子泵抑制剂、生长抑素和抗生素等常规治疗,并同时监测生命体征。观察组在对照组的基础上,采用血必净注射液静脉滴注及清胰汤口服、保留灌肠治疗。2组均以治疗7天为1个疗程。观察用药前后临床疗效,腹痛腹胀缓解时间,首次排便时间,血、尿淀粉酶恢复正常时间,血清反应蛋白(CRP)以及并发症发生率。总有效率对照组为77.5%,观察组为92.5%。观察组疗效优于对照组(P<0.05)。腹痛腹胀缓解时间、首次排便时间、血尿淀粉酶恢复正常时间观察组均短于对照组(P<0.05)。血清CRP治疗后2组均明显下降(P<0.05);观察组下降更明显(P<0.05)。并发症发生率观察组为22.50%,对照组为52.50%,2组比较差异有统计学意义(P<0.05)。结论:采用血必净注射液联合中药清胰汤治疗重症急性胰腺炎临床疗效显著,能改善SAP导致的肠道功能障碍及多脏器功能衰竭,减少并发症。

Objective： To observe therapeutic effects of Xue Bi Jing injection combined with Qing Yi Tang in treating severe acute pancreatitis（SAP）. Methods： Eighty SAP patients were randomized into the observation group and the control group, the control group were administered with anti-shock therapy, inhibiting pancreatic secretion,fasting, gastrointestinal decompression, routine treatment of proton pump inhibitor, somatostatin, antibiotics and others, simultaneously monitoring vital signs. The observation group received intravenous dripping of Xue Bi Jing injection, oral administration and retention enema of Qing Yi Tang. Seven days were one course of the treatment. To observe clinical effects, remission time of abdominal pain and distension, first defecating time, the time of amylase in blood and urine restoring to normal, serum CRP and the incidence of the complications. Results： Total effective rate of the control group was 77.5%, lower than 92.5% of the observation group. The observation group was superior to the control group in clinical effects（P〈0.05）. The observation group was shorter than the control group in remission time of abdominal pain and distension, first defecating time, the time of amylase in blood and urine restoring to normal（P〈0.05）. Serum CRP decreased in both groups after treating notably（P〈0.05）; the decrease of the observation group was more evident（P〈0.05）. The incidence of the complications of the observation group was 22.50%, lower than52.50% of the control group, the difference had statistical meaning（P〈0.05）. Conclusion： Xue Bi Jing injection combined with Qing Yi Tang are effective in treating SAP, the therapy could improve intestinal dysfunction and multiple organ failure induced by SAP, decrease the complications.