比较替比夫定与拉米夫定治疗慢性乙型肝炎的临床效果

Clinical Effect Comparation of Telbivudine and Lamivudine in Treatment of Chronic Hepatitis B

目的比较替比夫定与拉米夫定治疗慢性乙型肝炎的临床效果。方法将我院2012年8月~2015年8月收治的87例慢性乙型肝炎患者分为2组,观察组44例给予替比夫定治疗,对照组43例给予拉米夫定治疗,比较2组的临床效果。结果观察组总有效率为95.45%,不良反应发生率为9.09%,对照组总有效率为72.09%,不良反应发生率为11.63%,2组总有效率差异有统计学意义（P〈0.05）,不良反应发生率差异无统计学意义（P〉0.05）。结论替比夫定治疗慢性乙型肝炎的临床效果优于拉米夫定,其临床疗效较高,不良反应少。

Objective To compare telbivudine with lamivudine in the treatment of chronic hepatitis B clinical results.Methods The hospital in August 2012 to August 2015 were treated 87 cases of chronic hepatitis B patients were divided into two groups,the observation group 44 cases given telbivudine treatment,the control group of 43 patients received lamivudine comparison of the clinical effect of the two groups.Results The total effective rate was 95.45%,9.09% incidence of adverse reactions,the control group,the total effective rate was 72.09%,11.63% incidence of adverse reactions,there are two groups were statistically significant differences in overall efficiency（P〈0.05）,incidence of adverse reactions was no significant difference（P〉0.05）.Conclusion Telbivudine treatment of chronic hepatitis B clinical effect than lamivudine,higher clinical efficacy and less adverse reactions.