老年患者血清高密度脂蛋白胆固醇水平与冠状动脉粥样硬化性心脏病的相关性研究

Correlation between high density lipoprotein cholesterol and coronary atherosclerotic heart disease in elderly patients

目的 探讨老年患者血清高密度脂蛋白胆固醇（HDL-C）水平与冠状动脉粥样硬化性心脏病（冠心病）的相关性.方法 选择2011年1月至2014年8月在北京老年医院住院并行冠状动脉造影检查的老年患者214例,根据造影结果分为冠心病组（171例）和非冠心病组（43例）,测定2组患者空腹血清HDL-C水平并进行比较,分析HDL-C与冠心病的关系.结果 冠心病组患者血清HDL-C水平明显低于非冠心病组[（1.11 ±0.29） mmol/L比（1.27 ±0.34） mmol/L],差异有统计学意义（P＜0.01）.HDL-C是冠心病的保护因素（比值比=0.222,95％置信区间：0.057 ～0.869,P=0.031）.结论 血清HDL-C水平是冠心病的保护因素,是反映冠心病的一项重要生化指标。

Objective To evaluate the correlation between serum high density lipoprotein cholesterol （HDL-C） level and coronary atherosclerotic heart diseas in elderly patients.Methods A total of 214 elderly patients who underwent angiography from January 2011 to August 2014 were collected.According to the results of coronary angiography, the patients were divided into coronary atherosclerotic heart disease （CHD） group （171 cases） and non-CHD group （43 cases）.The serum HDL-C level was determined and compared between the two groups;the correlation between HDL-C level and coronary atherosclerotic heart disease was analyzed.Results The level of serum HDL-C in CHD group was significantly lower than that in non-CHD group [（1.11 ±0.29） mmol/L vs （1.27 ±0.34） mmol/L] （P 〈0.01）.HDL-C was a protective factor for CHD （P =0.031, odds ratio =0.222, 95% confidence interval： 0.057-0.869）.Conclusion Serum HDL-C provides a protective function for CHD.