细胞凋亡在体外循环肺损伤中的研究进展

Role of cell apoptosis in cardiopulmonary bypass related lung injury

体外循环(cardiopulmonary bypass,CPB)相关性肺损伤是心脏手术最常见的并发症,多数学者认为缺血再灌注损伤及全身炎症反应可能是CPB肺损伤发生的重要原因,但其具体机制尚有待阐明。近年来,细胞凋亡在此发病机制中日益受到重视,从凋亡的角度探寻CPB相关性肺损伤成为研究热点。文中主要就CPB肺组织细胞凋亡发生的特点、原因及其分子调控机制的最新研究展开综述。

Cardiopulmonary bypass（ CPB） related lung injury is the most common complication in cardiac surgery. Ischemia reperfusion injury and systemic inflammatory reaction may be the important causes of CPB-related lung injury,but the specific mechanism is still to be elucidated. In recent years,apoptosis is paid increasing attention in the pathogenesis of CPB. Therefore,cell apoptosis has been a hot spot in the research of CPB related lung injury. This article summarizes the latest researches on the characteristics,reasons and mechanisms of CPB-related pneumonocyte apoptosis.