摘要
马波沙星是动物专用第三代喹诺酮类抗菌药,其抗菌谱较广,活性较强。文章中以2,3,4,5-四氟苯甲酰氯为原料,经缩合、水解、胺转化等多步反应得到马波沙星,并对其进行了表征。该反应路线较已有路线,收率较高,绿色环保,更易于应用在工业生产中。
Marbofloxacin is animal-specific third-generation quinolone antibacterial agents; broad spectrum antimicrobial activity is strong. Article to 2,3,4,5-tetrafluoro benzoyl chloride as raw material, through a multi-step condensation reaction, hydrolysis, etc. get Marbofloxacin amine conversion, and its characterization. This route than the existing line, the higher the yield, the operation is more simple and easier to use in industrial production.
出处
《广东化工》
CAS
2015年第19期65-66,共2页
Guangdong Chemical Industry
关键词
马波沙星
合成
抗菌药
喹诺酮
mabrofloxacin
synthesis
antimicrobials
quinolone
