固骼生材料修复四肢骨折骨缺损:植骨融合效应

Nova Bone for repair of limb fractures: its effect on bone graft fusion

背景:新型骨修复材料固骼生具有独特的生物活性和良好的生物相容性,临床修复骨缺损可以发挥出良好的键合性,有效促进软组织及骨组织的键合。目的:分析固骼生材料修复四肢骨折所致骨缺损的临床效果。方法:纳入67例四肢骨折致骨缺损患者,其中男37例,女30例,年龄17-81岁,均实施固骼生材料修复治疗。修复后3 d,检测血常规、心肾功能及血清学补体C3、补体C4、免疫球蛋白G、免疫球蛋白A、免疫球蛋白M等水平;修复后随访12个月,X射线观察植骨融合效果。结果与结论:所有患者切口均一期愈合,未出现切口感染病例,各项实验室指标未见明显异常,未发生任何排斥和非特异炎症反应,植骨区未出现不适感或者异常症状;随访12个月,所有患者骨折均呈骨性愈合,植骨不融合1例,可能不融合1例,不确定融合2例,可能融合33例,坚强融合30例,植骨融合率为94%。表明采用固骼生材料修复四肢骨折所致骨缺损具有良好的生物相容性,修复效果良好,植骨融合率高。

BACKGROUND： As a new kind of bone repair material, Nova Bone has a unique biological activity and good biocompatibility. It has a good binding role in the clinical repair of bone defects, so as to effectively promote the bonding of soft tissue and bone tissue. OBJECTIVE： To explore the clinical effect of Nova Bone in the repair of bone defects due to limb fractures. METHODS： Sixty-seven patients with bone defects due to limb fractures were enrolled, 37 males and 30 females, aged 17-81 years. All the patients underwent Nova Bone repair. Three days after repair, routine blood test, heart and kidney function, serum complement C3, complement C4, immunoglobulin G, immunoglobulin A, immunoglobulin M were detected; 12 months after repair, X-ray observation was performed for bone graft fusion effect. RESULTS AND CONCLUSION： All patients presented with stage I healing, and there was no incision infection, rejection or non-specific inflammation. Patients felt no discomfort or developed symptoms in the bone graft region. Laboratory indexes showed no abnormity. At 12 months after treatment, bony union was seen in all patients, and there was 1 case of nonunion, 1 case of possible nonunion, 2 cases of uncertain nonunion, 33 cases of possible union, 30 cases of strong union, with a bone fusion rate of 94%. These findings suggest that Nova Bone materials for repair of bone defect due to limb fractures have good biocompatibility and obtain good clinical effect.