摘要
将聚阳离子壳聚糖(CS)与聚阴离子甲基丙烯酰氧乙基磷酰胆碱-甲基丙烯酸二元共聚物[poly(MPC-coMA),PMA30]通过聚电解质静电复合制备CS/PMA30水凝胶。然后,分别以中性红为模型药物,对CS/PMA30水凝胶的控释性能进行研究。结果表明:该CS/PMA30体系可以有效地控制中性红的释放速率,具有pH响应性及生物相容性,有望在药物控释、组织工程等领域具有巨大的应用前景。
The PMA30 was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine（MPC）and methacrylic acid（MA）with the MPC monomer molar percentage in the feed of 30%.The CS/PMA30 polyelectrolyte hydrogel was prepared through electrostatic interaction between chitosan（CS）polycation and PMA30 polyanions.In vitro drug release of neutral red from the CS/PMA30 hydrogel was determined by dialysis method.The results suggested that the CS/PMA30 hydrogel with phosphorylcholine groups was a good system for drug delivery due to pH-sensitive and biocompatibility may have potential applications in the fields of drug delivery,and tissue engineering.
出处
《化工新型材料》
CAS
CSCD
北大核心
2015年第10期179-181,共3页
New Chemical Materials
基金
陕西省自然基础研究计划(2014JQ2051)
西安科技大学博士启动金(2013QDJ013)
关键词
壳聚糖
磷酰胆碱
水凝胶
控释
chitosan
phosphorylcholine
hydrogel
controlled release
