异烟酰肼缩2-乙酰吡啶稀土配合物的制备、晶体结构及抗肿瘤活性（英文）

Syntheses, Crystal Structures and Antitumor Activities of Three Ln(Ⅲ) Complexes with 2-Acetylpyridine Picolinohydrazone

合成并通过元素分析,红外和X-射线单晶衍射表征了3个稀土配合物[Ln(HL)(NO3)3(CH3OH)2](Ln=La,1;Ce,2)和[Nd(HL)(NO3)3(H2O)]CH3OH(3)(HL=2-吡啶酰肼缩2-乙酰吡啶)。在同构配合物1和2中,中心金属离子与提供N2O配位原子的HL配体,3个双齿配位的硝酸根和2个甲醇分子配位,形成十一配位的单帽五角反棱柱配位构型。在配合物3中,中心金属离子采用十配位的模式与N2O配位构型的HL配体、3个双齿配位的硝酸根和1个水分子形成双帽四方反棱柱配位构型。2个配合物对人肠癌细胞Lovo,人胃癌细胞BGC823和SGC7901展现出显著的抗肿瘤活性。

Three lathanide（!II） complexes, namely [Ln（HL）（NO3）3（CH3OH）2] （Ln=La, 1; Ce, 2） and [Nd（HL）（NO3）3 （H20）]CH3OH （3） （HL=2-acetylpyridine picolinohydrazone）, have been isolated and characterized by elemental analyses, infrared spectra and single-crystal X-ray diffraction analyses. The results reveal that in the isostructure complexes 1 and 2, the eleven coordinated Ln all） ion with mono-capped pentagonal antiprism coordination geometry is surrounded by one HL ligand with N2O donor sets, three bidentate nitrate anion and two methanol molecules. In the complex 3, the Nd（Ⅲ） ion is coordinated by one HL ligand with N2O donor sets, three bidentate nitrate anions and one water molecule, thus exhibiting bicapped square antiprism coordination geometry. Furthermore, all the complexes have excellent antitumor activity towards Lovo human colorectal cancer, BGC823 and SGC7901 human gastric cancer cell lines. CCDC： 1402512, 1; 1402513, 2; 1402514, 3.