胃肠外科医师应重视结直肠癌的辅助化疗

结直肠癌的诊断和治疗是胃肠外科医师的主要工作之一。掌握结直肠癌手术后的辅助治疗．对许多胃肠外科医师至关重要。近年来，随着多项临床试验的开展和新药物的不断出现。结直肠癌的辅助化疗目前已经形成了以氟尿嘧啶药物为主联合奥沙利铂的方案。在当前的各种指南和规范中。Ⅲ期结肠癌是辅助化疗的指征，而Ⅱ期结肠癌是否需要接受辅助化疗尚无定论。另一方面，直肠癌的辅助治疗则缺乏足够的循证医学证据，尤其新辅助治疗后的直肠癌患者化疗的适应证仍存在很大争议。结直肠癌的辅助治疗仍需要开展进一步研究。

The diagnosis and treatment of colorectal cancer is one of the main diseases of gastrointestinal surgeons. It is very important to master the adjuvant chemotherapy of colorectal cancer for gastrointestinal surgeons. In recent years, with the development of a number of clinical trials and the appearance of new drugs, fluorouracil combined with oxaliplatin had been established as the standard regimen of adjuvant chemotherapy for colorectal cancer. In the current guidelines, stage Ⅲ colon cancer is the indication for adjuvant chemotherapy, while stageⅡ colon cancer should receive adjuvant chemotherapy is uncertain. Unlike colon cancer, adjuvant therapy of rectal cancer is not evidence-based. Especially, the indication and duration of adjuvant chemotherapy for rectal cancer after neoadjuvant chemoradiotherapy remain controversial. Adjuvant therapy of colorectal cancer still needs further investigation.