摘要
目的:比较分析胱抑素C(Cys C)、BUN、Scr、e GFR-MDRD和e GFR-cys等检测指标在诊断早期DN中的应用价值。方法:随机收集2012年1月至2014年10月本院收治的2型糖尿病(Type 2 diabetes mellitus,T2DM)患者214例和来本院体检的100名健康人,并根据尿蛋白排泄率分为单纯的T2DM组和糖尿病组(DN组),收集患者的血肌酐(Scr)、尿素氮(BUN)、血清胱抑素C(Cys C)等检测指标,并采用简化的MDRD公式根据Scr估算出e GFR(e GFR-MDRD),而Cys C则使用CHINAcys方程计算得出e GFR(e GFR-cys),对这些检测指标做统计学分析。结果:DN组和对照组相比BUN、Scr、Cys C、e GFRMDRD和e GFR-cys都有显著性变化,其中BUN、Scr和Cys C均显著高于对照组;e GFR-MDRD和e GFR-cys与对照组相比显著较低,5个检测指标均P<0.05;五个常用的检测指标ROS曲线面积都大于0.5,且P<0.05;单个检测指标中Cys C的检测指标最高能够达到80.38,其次是BUN和e GFR-MDRD;而联合检测中e GFR-MDRD+Cys C的灵敏度和约登指数远远高于e GFRMDRD+e GFR-cys和其他单项检测指标。结论:e GFR-MDRD结合Cys C指标的诊断对早期DN筛查是一种有效、可行且准确度较高的方法。
Objective:Comparative analysis detection indexes such as [ inhibition C ( CysC ) , BUN, Scr, eGFR-MDRD and eGFR-cys] of application value in the diagnosis of early DN.Methods: Randomly collected the Type 2 diabetes ( Type 2 diabetes mellitus,T2DM)214 cases patients to our hospital check-up and 100 healthy people from January 2012 to October 2014,and according to the urinary albumin excretion rate could divided into pure T2DM group and diabetes group(DN group),collected the patient′s serum creatinine( Scr) ,urea nitrogen( BUN) ,serum[ inhibition( Cys C) detection indexes such as C,and USES the simplified MDRD formula according to the Scr estimate the eGFR(eGFR-MDRD),while using CysC CHINAcys equation calculated eGFR,eGFR-Cys],make statistical analysis for these measurements.Results: DN group compared with control group ,the BUN,Scr,CysC,eGFR-MDRD and eGFR-cys had significant changes,including BUN,Scr and CysC was significantly higher than control group;EGFR-MDRD and eGFR-cys significantly lower compared with control group,5 testing indexes,P〈0.05.Five commonly used detection index curve of ROS area was greater than 0.5,and P〈0.05.A single detection index of CysC indicators could reach 80.38,the highest followed by BUN and eGFR-MDRD;And joint detection of eGFR MDRD+Cys C much higher sensitivity and an index of eGFR-MDRD+eGFR-Cys and other individual detection index.Conclusion:eGFR-MDRD CysC indicator in the diagnosis of early DN screening is an effective,feasible, and the method of high accuracy.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2015年第10期1394-1396,1399,共4页
Chinese Journal of Immunology
关键词
糖尿病肾病
早期诊断
胱抑素C
eGFR-MDRD
DN
Cystatin C
Early diagnosis
eGFR-MDRD