甲氨蝶呤、米非司酮联合益母调经合剂治疗胎盘粘连植入的疗效

Influence of Methotrexate, Mifepristone combined Motherwort Tiaojing mixture on placenta adhesion implanted patients' effect, ovarian function and inflammatory indicators

目的分析甲氨蝶呤、米非司酮联合益母调经合剂治疗胎盘粘连植入的疗效及对卵巢功能、炎症反应指标的影响。方法选择于2010年6月-2014年6月在该院接受住院治疗的胎盘粘连植入患者86例作为研究对象,按照随机数表法分为观察组(43例)接受甲氨蝶呤、米非司酮联合益母调经合剂治疗、对照组(43例)接受米甲氨蝶呤、米非司酮治疗,比较两组患者的治疗效果相关指标、卵巢功能及炎症反应指标等水平差异。结果 1观察组患者接受米非司酮联合益母调经合剂治疗后的72 h阴道出血量少于对照组,出血持续时间、胎盘排出时间、血人绒毛膜促性腺激素(HCG)降至正常时间等均明显短于对照组(P<0.05);2观察组患者接受治疗后的黄体生成激素(LH)、促卵泡激素(FSH)及雌激素(E2)水平均高于对照组(P<0.05);3观察组患者接受治疗后的血清C反应蛋白(CRP)、白介素-6(IL-6)及肿瘤坏死因子(TNF-α)水平均显著低于对照组(P<0.05)。结论甲氨蝶呤、米非司酮联合益母调经合剂治疗有助于胎盘粘连植入患者的胎盘完全娩出,同时减少出血及残留,具有保护患者卵巢功能、避免子宫感染等优势。

[ Objective ] To analysis influence of Methotrexate, mifepristone combined Motherwort Tiaojing mixture on placenta adhesion implanted patients＇ effect, Ovarian function and Inflammatory indicators. [ Methods ] 86 cases of placenta adhesion implanted patients between June 2010 to June 2014 in our hospital as research object, accord- ing to random indicator method divided into observation group （43 cases） treated with Methotrexate, mifepristone combined Motherwort Tiaojing mixture, control group （43 cases） treated with Methotrexate, mifepristone, compare cu- rative effect related indicators, ovarian function, inflammation index level. [ Results ] 1）Observation group patients 72 hours of vaginal haemorrhage amount was less than control group, bleeding duration, placenta discharge time and blood HCG dropped to normal time were significantly shorter than control group （P 〈 0.05）; 2）observation group patients LH, FSH, E2 levels were higher than control group （P 〈 0.05）;3）observation group serum CRP, IL-6 and TNF alpha levels were significantly lower than control group （P 〈 0.05）. [Conclusion] Methotrexate, Mfepristone com- bined Motherwort Tiaojing mixture help patients with placenta adhesion implanted placenta completely childbirth, reduce bleeding and residue at the same time, avoid uterine infection in patients with ovarian function.