参附注射液治疗老年重症肺炎的效果及影响因素的Logistic回归分析

Effects of Shenfu Injection on Elderly Patients with Severe Pneumonia and Logistic Regression Analysis of Infl uencing Factors

目的分析参附注射液治疗老年重症肺炎的效果及影响因素,为进一步提高参附注射液的临床应用提供参考依据。方法收集2011年1月至2014年1我院呼吸科治疗的184例老年重症肺炎患者,以治疗过程中全程加用参附注射液的患者为病例组,以未加用者为对照组。收集患者临床资料,应用Logistic回归分析影响参附注射液治疗老年重症肺炎效果的主要因素。结果以治疗10 d为观察点,病例组好转44例,迁延38例、死亡16例,对照组好转22例,迁延35例、死亡29例,两组比较差异有统计学意义(λ2=10.474,P=0.005)。Logistic回归分析显示观察组的治疗效果优于对照组(OR=2.557);患者慢性基础疾病、抗生素实用情况、鲍曼不动杆菌感染、肺炎患者的Fine分级等对疗效有影响。结论参附注射液对老年重症肺炎有较好的治疗效果,临床应用中注意患者慢性基础疾病、抗生素实用情况、细菌感染情况等的影响。

Objective Analyze the main factors influencing the therapeutic effects of Shenfu injection on elderly patients with severe pneumonia by multivariate Logistic regression analysis, in order to provide a reference for clinical application. Methods 184 elderly patients with severe pneumonia（from 2011.1to 2014.1）were retrospectively analyzed. The case group was defi ned as the administration Shenfu injection on the basis of integrated western medicine treatment and without as control group. Clinical data were reviewed and the potential infl uencing factors were analyzed by Logistic regression. Results 38 cases were improved, 17 cases progressed and 15 cases died in observation group while 18 cases were improved, 19 cases progressed and 30 cases died in the control group after 14 d（P 0.05）. Logistic regression analysis showed that therapeutic effects in observation group was superior to the control group（OR = 2.557）; and patients＇ chronic underlying conditions, antibiotics and practical situation, acinetobacter baumannii infection and pneumonia patients＇ Fine classifi cation will infl uence the therapeutic effects. Conclusion Shenfu injection has a better effect on elderly patients with severe pneumonia. Patients＇ chronic diseases, antibiotics situation, bacterial infections and pneumonia patients＇ Fine classifi cation are factors infl uencing the therapeutic effects.