摘要
目的利用软骨延迟增强磁共振成像(dGEMRIC)技术评估基质诱导的自体软骨细胞移植(MACI)术后移植软骨的GAG分层分布特点。方法 7例MACI术后患者(14处软骨缺损)在术后3、6、12个月进行dGEMRIC检查,测量正常软骨和移植软骨的全层和深浅层△R1值。各时间点正常软骨和移植软骨△R1值的比较采用配对t检验。各时间点间移植软骨的△R1值变化采用单因素方差分析。结果 MACI术后各时间点正常软骨全层△R1值均小于移植软骨△R1值(P均<0.05)。MACI术后各时间点移植软骨深层△R1值小于浅层△R1值,差异具有统计学意义(P均<0.05)。MACI术后3个月与6个月移植软骨△R1值的比较不具有统计学意义(P均>0.05),而术后6个月移植软骨△R1值明显大于12个月移植软骨△R1值,且差异具有统计学意义(P均<0.05)。结论 dGEMRIC技术可作为无创性评估移植软骨的修复过程的有效手段。
Objective To estimate zonal variation of GAG content in reparative cartilage after matrix associated autologous chondrocyte implantation(MACI) using delayed gadolinium-enhanced magnetic resonance imaging of the cartilage(d GEMRIC).Methods Seven patients(14 cartilage defects) undergoing MACI were recruited for examination with d GEMRIC at 3, 6, and 12 months after the procedure to calculate global and zonal longitudinal relaxivity(△R1) of the normal cartilage and reparative cartilage. Results The mean △ R1 values of normal cartilage were significantly lower than those of reparative cartilage after MACI. A significant decrease was noted in the mean △R1 values from the deep layer to the superficial layer in the reparative cartilage at the 3 examinations. The △R1 values of the reparative cartilage showed no significant variation between 3 months and 6 months, but a significant decrease in the △R1 values occurred at 12 months. Conclusion d GEMRIC is feasible to assess cartilage repair noninvasively following MACI.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2015年第10期1467-1471,共5页
Journal of Southern Medical University
关键词
软骨延迟增强磁共振成像
自体软骨细胞移植
关节软骨
软骨修复
delayed gadolinium-enhanced magnetic resonance imaging of the cartilage
autologous chondrocyte implantation
articular cartilage
cartilage repair