妊娠期糖尿病高危孕妇甲状腺功能变化分析

Thyroid function change in pregnant women with gestational diabetes mellitus

目的：探讨妊娠期糖尿病（ gestational diabetes mellitus ，GDM）高危孕妇甲状腺功能的变化。方法选取浙江苍南县人民医院产科2013年2月至2014年6月GDM高危孕妇80例，将其设为A1组（高危组）；选择GDM孕妇80例，设为A2组（糖尿病组）；选择正常健康孕妇80例，设为A3组（对照组）；对3组孕妇甲状腺功能指标进行检测，并进行比较分析。结果 A1与A2组的TPOAb阳性率水平显著高于A3组，差异有统计学意义（P＜0.05）；3组孕妇的TSH、FT3指标比较差异无统计学意义（P＞0.05），但A1与A2组的FT4水平显著低于A3组，差异有统计学意义（ P＜0.05）。结论 GDM孕妇及高危孕妇出现甲状腺功能异常的概率较正常健康孕妇更高，特别是有糖尿病家族史的孕妇，临床上应全面检查其甲状腺功能，防止因甲状腺功能紊乱对患者妊娠造成严重的影响，有效保证患者临床安全性。

Objective To investigate changes of thyroid functions in high-risk pregnant women suffering from gestational diabetes mellitus（GDM）.Methods From Feb.2013 to Jun.2014, 80 cases of high-risk preg-nant women suffering from GDM were selected as group A1（high-risk group）, 80 cases of GDM pregnant women were selected as group A2（diabetic group）, and 80 cases of healthy pregnant women were selected as group A 3 （ the control group ） .Indicators of thyroid function for the three groups were detected and compared .Results The positive rate of TPOAb in group A1 and A2 was significantly higher than that in group A 3, and the difference had statistical significance（P〈0.05）.The difference of TSH and FT3 had no statistical significance between the three groups（P〉0.05）, while FT4 level in group A1 and A2 was both significantly lower than that in group A3, and the difference had statistical significance （P〈0.05）.Conclusions The probability of thyroid dysfunction in GDM pregnant women and high-risk pregnant women is higher than that in the normal healthy pregnant women . For pregnant women with a family history of diabetes , thyroid functions should be checked comprehensively to prevent thyroid dysfunction .