高寒地区老年人骨密度相关因素分析

Analysis of the influential factors of bone mineral density in the elderly living in high altitude area

目的探讨老年人群骨密度(BMD)与25-羟维生素D(25OHD)的相关性,为防治老年人骨质疏松提供可靠的临床理论依据。方法选择我院2013年3月至2014年10月,年龄大于60岁的老年患者的临床资料共647例。采用双能X线骨密度仪,进行骨密度测定。将骨密度分为骨质疏松组、低骨量组、骨密度正常组,对比各组的年龄、身高、体重及血清中25羟维生素D的含量,并将骨密度与以上各指标进行相关性分析。结果老年患者的身高、体重及25OHD均随着骨密度的升高而增加,差异有统计学意义,P<0.0001;且骨密度均与身高、体重及25OHD分别呈相关,相关系数分别为0.303、0.174和0.25;多元线性回归分析显示,身高、体重及25OHD分别是骨密度的影响因素。结论老年患者中的身高、体重及25OHD均是骨密度的影响因素,检测血清中25OHD的含量可为老年人防治骨质疏松提供可靠的临床依据。

Objective To investigate the correlation between bone mineral density （BMD） and 25- hydroxyl-vitamin D （25OHD） in the elderly, in order to provide reliable clinical theoretical basis for the prevention and treatment of senile osteoporosis. Methods A total of 647 older than 60-year patients were selected in our hospital from 2013 March to 2014 October. BMD was measured using DXA. According to BMD, the patients were divided into osteoporosis group, low bone mass group, and normal BMD group. Age, height, body weight, and serum 25OHD content were compared among the groups. The correlation between BMD and above parameters was analyzed. Results The height, weight, and 25OHD content increased with the increase of BMD in the elderly patients, and the difference was statistically significant （ P 〈 0. 0001 ）. BMD was associated with body weight, height, and 25OHD, and the correlation coefficients were 0. 303, 0. 174, and 0. 25, respectively. Multivariate linear regression analysis showed that body weight, height, and 25OHD were influential factors of BMD. Conclusion Height, weight, and 25OHD are influential factors of BMD in the elderly. Detection of serum 25OHD content can provide reliable clinical basis for prevention and treatment of osteoporosis in the elderly.