变应性鼻炎特异性免疫治疗近期疗效观察及影响因素分析

Short-term efficacy and factors of specific immunotherapy on patients with allergic rhinitis

目的:观察变应性鼻炎(AR)特异性免疫治疗(SIT)近期疗效,并探讨影响其疗效的相关因素。方法:比较57例接受SIT的螨过敏患者治疗前及进入维持期后的症状评分、视觉模拟量表(VAS)评分、用药评分,利用t检验及Spearman相关分析研究患者年龄、性别、皮肤点刺试验(SPT)和血清sIgE等级与疗效的相关性。结果:SIT治疗前后患者症状评分、VAS评分、用药评分均差异有统计学意义;但患者性别、年龄、SPT和血清sIgE等级与SIT近期疗效不具有显著的相关性。结论:AR的SIT是一种行之有效的治疗方法,在变应原明确诊断后应尽早应用。

Objective：To evaluate the short-term efficacy and investigate the factors of specific immunotherapy （SIT） efficacy of allergic rhinitis. Method： Fifty-seven patients with allergic rhinitis to dermatophagoides pteronyssinus were included to receive SIT. Pair t-test was used to compare the symptom scores, visual analogue scores （VAS） and medication scores in patients before SIT and into maintain treatment statement to evaluate the clinical efficacy. T-test and Spearman correlation analysis were used to analyze the correlation between gender,age,reac- tion condition of skin prick test（SPT） and serum sIgE and theefficacy of SIT. Result：SIT was able to significantly reduce the symptom scores, VAS and medication scores. But the correlation between gender, age, SPT, and slgE and theefficacy of SIT were not significant. Conclusion：SIT is effective in the short-term treatment of AR. Further research is needed to investigate the factors that impact the efficacy of SIT.