摘要
目的 比较卵巢交界性肿瘤患者行保留生育功能的单侧附件切除术（USO）与囊肿剥除术（CYS）发生术中囊肿破裂、术后复发与术后妊娠情况的差异.方法 系统检索PubMed、Embase、Cochrane Library及全中文数据库,搜索卵巢交界性肿瘤、保留生育功能手术、单侧附件切除术与囊肿剥除术的前瞻性及回顾性研究,阅读全文,提取资料中对照试验,利用Review Manager 5.2进行系统评价.结果 最终纳入6篇文献,483例患者.Meta分析结果显示：①USO术中囊肿破裂率较CYS低,RR=0.73,P=0.06,95%CI（0.52~1.01）,差异无统计学意义.②术后复发率USO较CYS低,RR=0.48,P=0.004,95%CI（0.32~0.72）,差异有统计学意义.③术后共144例患者有妊娠愿望,其中USO组98例,59例成功妊娠;CYS组56例,29例成功妊娠,OR=1.26,P=0.54,95%CI（0.81, 1.48）,差异无统计学意义.结论 BOT患者采用单侧附件切除术及囊肿剥除术均有一定的术后妊娠率,但单侧附件切除术较囊肿剥除术更安全.
Objective To evaluate the efficacy and safety of unilateral salpingo-oophorectomy （USO） and cystectomy （CYS） as fertility-sparing therapy in treating borderline ovarian tumor （BOT） by comparing their rates of cyst rupture during operation, postoperative recurrence and postoperative pregnancy. Methods Prospective and retro-spective studies on BOT, fertility-sparing surgery, USO and CYS were searched from database such as PubMed, Co-charane Library, EMbase, CNKI, VIP and Wanfang. Cinical controlled trails （CCTs） were extracted from these studies, and meta-analysis was performed using Review Manager 5.2 software. Results Six studies involving 483 patients were included. The results of meta-analysis showed that：（1） The rate of cyst rupture during operation of USO was low-er than that of CYS, with RR=0.73, P=0.06, 95%CI（0.52, 1.01）, and the difference was not statistically significant. （2） The postoperative recurrence rate of USO was lower than that of CYS. RR=0.48, P=0.004, 95%CI（0.32, 0.72）, and the difference was statistically significant. （3） After operation, a total of 144 patients tried to conceive, with 98 patients in the USO group and 56 in the CYS group. And it turned out that there were 59 successful cases in the USO group and 29 in the CYS group, with OR=1.26, P=0.54, 95%CI（0.81, 1.48）, and the difference was not statistically significant. Conclusion Both USO and CYS can bring BOT patients chances of pregnancy, while USO tended to be safer.
出处
《海南医学》
CAS
2015年第19期2934-2938,共5页
Hainan Medical Journal
