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紫杉醇脂质体化疗联合三维适形放疗治疗局部晚期非小细胞肺癌的疗效观察 被引量:15

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摘要 目的探讨紫杉醇脂质体化疗联合三维适形放疗治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效及其安全性。方法选择2012年1月至2014年6月晚期NSCLC患者86例,随机分为对照组和观察组各43例,对照组应用紫杉醇与顺铂治疗,观察组则应用紫杉醇脂质体化疗联合三维适形放疗。两组均3周为一个疗程,治疗3个疗程后进行评估。评估两组患者的临床治疗效果和不良反应,检测并比较治疗前后患者的空腹静脉血癌胚抗原(CEA)、糖类抗原125(CA125)水平。结果观察组的总治疗有效率为72.09%,高于对照组的49.06%,差异有统计学意义(P<0.05);观察组治疗后的CEA和CA125分别为(36.40±6.14)ng/ml和(56.29±7.26)U/ml,均低于对照组的(59.93±6.75)ng/ml和(81.87±7.32)U/ml,差异均有统计学意义(P<0.05);观察组患者消化道反应评分高于对照组,白细胞也高于对照组,差异均有统计学意义(P<0.05)。结论紫杉醇脂质体化疗联合三维适形放疗治疗局部晚期非小细胞肺癌具有较好的临床疗效,能够减少患者并发症。
作者 申增能 胡蓉
出处 《海南医学》 CAS 2015年第20期3056-3058,共3页 Hainan Medical Journal
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