期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乳腺癌干细胞标志物及乳腺癌干细胞治疗策略 被引量：3

下载PDF
导出
摘要 乳腺癌干细胞(BCSCs)是一类具有自我更新能力的多潜能细胞,在一定条件下可以分化成多种功能性细胞,对乳腺癌的发生具有始动作用。临床常规的放射治疗、化学治疗不能有效杀死BCSCs,并且因其具有高致瘤性、转移性、耐药性等特点,成为乳腺癌治疗失败和复发转移的根源。因此,探讨BCSCs的生物学特性和表型特征,有助于寻找有效靶向BCSCs的治疗技术和策略,从而提高乳腺癌的临床治疗效果。本文就BCSCs的标志物及其治疗方面的新进展进行综述。
作者 王慧 康欣梅
机构地区 哈尔滨医科大学附属肿瘤医院内科
出处 《新乡医学院学报》 CAS 2015年第10期964-967,971,共5页 Journal of Xinxiang Medical University
关键词 乳腺癌 乳腺癌干细胞 标志物
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献36

  • 1Ma F,Li H,Wang H,et al.Enriched CD44+/CD24-population drives the aggressive phenotypes presented in triple-negative breast cancer(TNBC)[J].Cancer Lett,2014,353(2):153-159.
  • 2Bonnet D,Dick J E.Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J].Nat Med,1997,3(7):730-737.
  • 3Al-Hajj M,Wicha M S,Benito-Hernandez A,et al.Prospective identification of tumorigenic breast cancer cells[J].Proc Natl Acad Sci U S A,2003,100(7):3983-3988.
  • 4王磊,杨海杰,张彬彬,冯志伟.肿瘤干细胞的生物学特性、来源及临床应用[J].新乡医学院学报,2015,32(7):591-595. 被引量：2
  • 5Giatromanolaki A,Sivridis E,Fiska A,et al.The CD44+/CD24-phenotype relates to'triple-negative'state and unfavorable prognosis in breast cancer patients[J].Med Oncol,2011,28(3):745-752.
  • 6Alamgeer M,Ganju V,Kumar B,et al.Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer[J].Breast Cancer Res,2014,16(2):R44.
  • 7Zheng R,Wang J,Wu Q,et al.Expression of ALDH1 and TGFβ2in benign and malignant breast tumors and their prognostic implications[J].Int J Clin Exp Pathol,2014,7(7):4173-4183.
  • 8崔军威,李朋,刘志兰,聂李平,于志强,林丽芬,韩彬,韦伟.ALDH^(hi)CD44^+细胞在乳腺癌组织中的表达及其与相关细胞信号传导通路之关系研究[J].吉林医学,2013,34(16):3077-3082. 被引量：2
  • 9Liu L,Salnikov A V,Bauer N,et al.Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation[J].Int J Cancer,2014,134(10):2489-2503.
  • 10Wang X,Hu J F,Tan Y,et al.Cancer stem cell marker Musashi-1rs2522137 genotype is associated with an increased risk of lung cancer[J].PLo S One,2014,9(5):e95915.

二级参考文献29

  • 1Ma L, de Roquancourt A, Bertheau P, et al. Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and paracriny. J Pathol, 2001, 194:412-418.
  • 2Ma L, Gauville C, Berthois Y, et al. Role of epidermal-growth-factor receptor in tumor progression in transformed human mammary epithelial cells. Int J Cancer, 1998, 78:112-119.
  • 3Ma L, Gauville C, Berthois Y, et al. Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line. Oncogene, 1999, 18:6513-6520.
  • 4Wellmann S, Taube T, Paal K, et al. Specific reverse transcription-PCR quantification of vascular endothelial growth factor (VEGF) splice variants by LightCycler technology. Clin Chem, 2001, 47:654-660.
  • 5Berquin IM, Dziubinski ML, Nolan GP, et al. A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene, 2001, 20:4019-4028.
  • 6Kato T, Kameoka S, Kimura T, et al. The combination of angiogenesis and blood vessel invasion as a prognostic indicator in primary breast cancer. Br J Cancer, 2003, 88:1900-1908.
  • 7Gille J, Swerlick RA, Caughman SW. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J, 1997, 16:750-759.
  • 8Bouras T,Pal B,Vaillant F,etal.Notch signaling regulatesmammary stem cell function and luminal cell-fate commitment[J].Cell stem cell,2008,3(4):429.
  • 9Thomas Schlange,Yutaka Matsuda,etal.Autocrine WNT sig-naling contributes to breast cancer cell proliferation via the canoni-cal WNT pathway and EGFR transactivation[J].Breast Cancer Re-search,2007,9(5):R63.
  • 10Emmanuelle Charafe-Jauffret,Christophe Ginestier,FloraIovino,etal.Breast cancer cell lines contain functional cancer stemcells with metastatic capacity and a distinct molecular signature[J].Cancer Res,2009,69(4):1302.

共引文献9

同被引文献29

  • 1WAGGONER D W,XU J,SINGH I,et al.Structural organization of mammalian lipid phosphate phosphatases:implications for signal transduction[J].Biochim Biophys Acta,1999,1439(2):299-316.
  • 2KANOH H,KAI M,WADA I.Phosphatidic acid phosphatase from mammalian tissues:discovery of channel-like proteins with unexpected functions[J].Biochim Biophys Acta,1997,1348(1/2):56-62.
  • 3SCIORRA V A,MORRIS A J.Roles for lipid phosphate phosphatases in regulation of cellular signaling[J].Biochim Biophys Acta,2002,1582(1/2/3):45-51.
  • 4WOOLSTON C.Breast cancer:4 big questions[J].Nature,2015,527(7578):S120.
  • 5QUIROGA-GARCíA V,CIRAUQUI-CIRAUQUI B,BUGéS-SáNCHEZ C,et al.Primary hormone therapy in elderly women with hormonesensitive locoregional breast cancer:endocrine therapy alone is a reasonable alternative in selected patients[J].Breast Care(Basel),2015,10(3):179-183.
  • 6COUGHLIN S S,SMITH S A.The Impact of the natural,social,built,and policy environments on breast cancer[J].J Environ Health Sci,2015,1(3):1-7.
  • 7ENGEL C,FISCHER C.Breast cancer risks and risk prediction models[J].Breast Care(Basel),2015,10(1):7-12.
  • 8AUPPERLEE M D,ZHAO Y,TAN Y S,et al.Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet[J].Breast Cancer Res,2015,17(1):138-158.
  • 9BENJAMIN D I,LI D S,LOWE W,et al.Diacylglycerol metabolism and signaling is a driving force underlying FASN inhibitor sensitivity in cancer cells[J].ACS Chem Biol,2015,10(7):1616-1623.
  • 10BRINDLEY D N,PILQUIL C.Lipid phosphate phosphatases and signaling[J].J Lipid Res,2009,50(Suppl):S225-S230.

引证文献3

二级引证文献12

新乡医学院学报
2015年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部