芥子气肺损伤机制研究进展

Mechanisms of lung injuries exposed to sulfur mustard:recent advances

芥子气(SM)是一种亲脂糜烂性烷化剂,可通过呼吸道、角膜、皮肤等途径吸收至体内损伤全身器官。SM不仅能对DNA、蛋白质、核酸烷化产生其独有的细胞毒,而且还是一种较强的诱变原和致癌原。无论何种途径SM中毒,肺是最容易损伤的靶器官,且急性呼吸窘迫综合征和肺部感染成为SM早期致死的主要原因。本文就SM所致炎症细胞和细胞因子产生的炎症反应、多因素引发的多通路细胞凋亡失衡、细胞毒导致的DNA烷化效应和阻断细胞代谢诱发的氧化应激反应等肺损伤机制的研究现状作一概述。

Sulphur mustard（SM）is a corrosive alkylating agent that is likely to be absorbed in vivo through the lungs,eyes and skin into internal organs. SM not only can produce its peculiar cytotoxicity thought to be mediated by the alkylation of DNA,protein and nucleic acids,but is a strong mutagen and carcinogen. However,whatever the way SM poisoning occurs,lungs are the most vulnerable,and early death is mainly carused by both the acute respiratory distress syndrome and pulmonary infection. In this review,we analyzed SM-induced lung injury mechanisms.