氯丙嗪、氯氮平、奋乃静治疗的精神分裂症患者换用维思通治疗后血常规结果的变化及分析

Analysis on the changes of routine blood tests results after therapy of chlorpromazine,clozapine or perphenazine changed to risperidone in schizophrenic patients

目的探讨将氯丙嗪、氯氮平、奋乃静换为维思通治疗精神分裂症后患者血常规检查结果的改变情况。方法选取2014年3月至2015年3月于本院进行治疗的100例精神分裂症患者。患者先用氯丙嗪、氯氮平或奋乃静治疗一个疗程,然后换用维思通进行治疗。结果换药治疗后,患者的红细胞平均体积大于换药前。淋巴细胞计数多于换药前,中间细胞计数明显低于换药前,差异均有统计学意义(P<0.05)。结论采用氯丙嗪、氯氮平或奋乃静治疗的精神分裂症患者改用维思通治疗后,白细胞分化有所改变,红细胞平均容积明显增大。

Objective To study the blood routine tests results change after therapy of chlorpromazine ,clozapine ,perphenazine changed to risperidone in schizophrenic patients .Methods 100 schizophrenic patients in the hospital from March 2014 to March 2015 for treatment were enrolled in the study ,who were treated with chlorpromazine ,clozapine or perphenazine respectively for one course ,and then the therapies were replace by risperdal .Results After treatment ,mean corpuscular volume was significantly grea‐ter ,the number of lymphocytes was significantly higher and intermediate cell number was significantly lower than that before treat‐ment ,the difference was statistically significant（P〈0 .05） .Conclusion Leukocyte differentiation change and mean corpuscular vol‐ume increased obviously after therapy of chlorpromazine ,clozapine or perphenazine changed to risperidone in schizophrenic patients .