巨大腹膜后Castleman病1例报告并文献复习

Retroperitoneal Castleman′s disease:report of 1 cases and literature review

目的探讨腹膜后Castleman病(Castleman′s disease,CD)的临床特点及治疗方法。方法回顾分析1例腹膜后肾上腺区巨大CD患者的临床资料,并结合文献进行讨论。患者以反复口腔溃疡症状就诊,术前有CT等影像学表现,未能明确诊断,肿块位于左肾旁及左肾上腺区,拟采用经腹手术探查。结果患者手术顺利,术后病理证实为腹膜后巨大CD,血管滤泡型增生,术后患者周身皮损及口腔溃疡症状消失,随访1年无肿瘤复发。结论腹膜后CD临床罕见,临床医生多缺乏对此病的系统认识,术前诊断困难,确诊主要依靠病理和免疫组化检查,手术切除肿瘤是首选治疗方式,有望达到治愈目的。

Objective To discuss the clinical characteristics and treatment methods of retro- peritoneal Castlemaffs disease （CD）. Methods We retrospectively analyzed 1 case of huge retro- peritoneal Castleman tumor located in adrenal area in our hospital in 2014. This patient had a repeated oral ulceration and CT scan shows that the mass locates in left adrenal area. Consequently the patient received surgery treatment. Results Patients were confirmed by pathology huge retroperitoneal lymph tissue hyperplasia, vascular follicular hyperplasia, After surgery this patient was followed up for 1 year and there was no tumor and ulceration recurrence. Conclusions Retroperitoneal CD is a rare tumor, which is difficult in preoperative diagnosis. The final diagnosis mainly depends on the pathology and immunohistochemical examination. Surgery is the most preferred treatment to the disease.