抑郁障碍与双相障碍脑血流灌注研究

Single emission computed tomography of cerebral blood flow between unipolar depressed patients and bipolar depressed patients

目的探讨抑郁障碍和双相障碍患者局部脑血流量(regional cerebral blood flow,r-CBF)特点及差异。方法纳入未经治疗的发作期抑郁障碍(major depression disorder,MDD)、双相障碍抑郁发作(bipolar disorder,BPD)患者各22例及15名健康对照,采用单光子发射型计算机断层扫描(single-photon emission computed tomography,SPECT)进行局部脑血流灌注显像,并比较各组的局部血流灌注情况。结果与对照组相比,MDD、BPD患者均存在双侧颞叶、顶叶、基底节血流灌注降低(P<0.001),MDD患者基底节灌注低于BPD患者(P<0.001)。结论 MDD、BPD患者均存在静息状态脑血流灌注下降,基底节灌注不同是BPD与MDD患者脑血流灌注特征的主要差异。该差异或许可视为鉴别MDD与BPD的生物学标记。

ObjectiveTo investigate the characteristic of regional cerebral blood flow（r-CBF） in patients with major depression disorder（MDD） and bipolar depressed（BPD）.MethodsThe r-CBF imaging was detected by using single emission computed tomography（SPECT） in 22 treatment naive patients with MDD, 22 treatment naive patients with BPD and 15 healthy controls. The r-CBF was compared between patients and controls.ResultsCompared to controls,the r-CBF in the bilateral temporal lobe, parietal lobe and basal ganglia significantly decreased in MDD and BPD patients（P0.001）. The r-CBF in the basal ganglia was significantly lower in MDD patients than in BPD patients.ConclusionThe r-CBF is abnormal in MDD and BPD at the resting state. The r-CBF in the basal ganglia is the main difference between MDD and BPD. The difference might be regarded as a biomarker in distinguishing BPD patients from MDD patients.