IL-17基因rs2275913多态性与胃癌易感性的Meta分析

Association between rs2275913 polymorphism in IL-17 gene and gastric cancer susceptibility: a Meta-analysis

目的：探讨IL-17基因rs2275913多态性与胃癌易感性的关系。方法：检索多个国内外数据库,收集有关IL-17基因G〉A多态性位点rs2275913（G197A）与胃癌易感性的病例-对照研究。筛选文献、提取数据和文献质量评价后,采用STATA 12.1统计软件进行Meta分析。结果：最终纳入10个病例-对照研究,其中病例组4 371例,对照组5 345例。Meta分析结果显示,IL-17基因rs2275913位点多态性的等位基因模型（A vs.G）（OR=1.22,95%CI=1.10~1.37）与相加模型（AA vs.GG）（OR=1.58,95%CI=1.23~2.04）胃癌风险增加,显性模型（AG＋GG vs.AA）（OR=0.63,95%CI=0.48~0.84）、隐性模型（GG vs.AG＋AA）（OR=0.86,95%CI=0.78~0.94）胃癌风险降低（均P〈0.05）,但共显性模型（AG vs.AA＋GG）（OR=0.91,95%CI=0.78~1.07）与罹患胃癌的风险无明显关系（P〉0.05）。结论：IL-17基因rs2275913多态性的与胃癌易感性密切相关。

Objective：To investigate the association between rs2275913 site polymorphism of IL-17 gene and the risk of gastric cancer.Methods：The case-control studies on relationship between the IL-17 rs2275913 GA polymorphism and gastric cancer susceptibility were collected by searching several national and international databases.After literature screening,data extraction and quality assessment,Meta-analysis was performed by STATA 12.1 software.Results：Ten case-control studies were finally included,with 4 371 patients in case group and 5 345 subjects in control group.Meta-analysis results showed that among the rs2275913 site polymorphisms of IL-17 gene,the risk of gastric cancer was increased under allele-contrast model（A vs.G）（OR=1.22,95%CI=1.10-1.37） and additive model（AA vs.GG）（OR=1.58,95%CI=1.23-2.04）,and was decreased under dominant model（AG＋GG vs.AA）（OR=0.63,95%CI=0.48-0.84） and recessive model（GG vs.AG＋AA）（OR=0.86,95%CI=0.78-0.94）,but had no obvious change under codominant model（AG vs.AA＋GG）（OR=0.91,95%CI=0.78-1.07）.Conclusion：IL-17 rs2275913 polymorphism is closely related to gastric cancer susceptibility.