摘要
目的:探讨IL-17基因rs2275913多态性与胃癌易感性的关系。方法:检索多个国内外数据库,收集有关IL-17基因G〉A多态性位点rs2275913(G197A)与胃癌易感性的病例-对照研究。筛选文献、提取数据和文献质量评价后,采用STATA 12.1统计软件进行Meta分析。结果:最终纳入10个病例-对照研究,其中病例组4 371例,对照组5 345例。Meta分析结果显示,IL-17基因rs2275913位点多态性的等位基因模型(A vs.G)(OR=1.22,95%CI=1.10~1.37)与相加模型(AA vs.GG)(OR=1.58,95%CI=1.23~2.04)胃癌风险增加,显性模型(AG+GG vs.AA)(OR=0.63,95%CI=0.48~0.84)、隐性模型(GG vs.AG+AA)(OR=0.86,95%CI=0.78~0.94)胃癌风险降低(均P〈0.05),但共显性模型(AG vs.AA+GG)(OR=0.91,95%CI=0.78~1.07)与罹患胃癌的风险无明显关系(P〉0.05)。结论:IL-17基因rs2275913多态性的与胃癌易感性密切相关。
Objective:To investigate the association between rs2275913 site polymorphism of IL-17 gene and the risk of gastric cancer.Methods:The case-control studies on relationship between the IL-17 rs2275913 GA polymorphism and gastric cancer susceptibility were collected by searching several national and international databases.After literature screening,data extraction and quality assessment,Meta-analysis was performed by STATA 12.1 software.Results:Ten case-control studies were finally included,with 4 371 patients in case group and 5 345 subjects in control group.Meta-analysis results showed that among the rs2275913 site polymorphisms of IL-17 gene,the risk of gastric cancer was increased under allele-contrast model(A vs.G)(OR=1.22,95%CI=1.10-1.37) and additive model(AA vs.GG)(OR=1.58,95%CI=1.23-2.04),and was decreased under dominant model(AG+GG vs.AA)(OR=0.63,95%CI=0.48-0.84) and recessive model(GG vs.AG+AA)(OR=0.86,95%CI=0.78-0.94),but had no obvious change under codominant model(AG vs.AA+GG)(OR=0.91,95%CI=0.78-1.07).Conclusion:IL-17 rs2275913 polymorphism is closely related to gastric cancer susceptibility.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2015年第10期1356-1362,共7页
China Journal of General Surgery