自噬相关蛋白Beclin 1在胃癌组织中表达意义的Meta分析

Significance of autophagy-related protein beclin 1 expression in gastric cancer: a Meta-analysis

目的：系统评价胃癌组织中自噬相关蛋白Beclin 1（BECN1）的表达及其与胃癌患者临床病理特征之间的相关性。方法：检索国内外相关数据库,收集2015年2月1日前发表的关于胃癌组织中BECN1的表达及其临床意义的研究,提取相关数据,采用Rev Man 5.3及Stata12.0软件进行Meta分析。结果：最终纳入了9个研究,其中包含胃癌患者1 620例。Meta分析结果显示,胃癌组织中BECN1的表达阳性率明显低于非胃癌组织（OR=0.11,95%CI=0.02~0.62,P=0.01）;高分化胃癌组织的BECN1表达阳性率明显高于中低分化胃癌组织（OR=14.30,95%CI=5.94~34.4,P=0.000）;无远处转移患者的胃癌组织中BECN1表达阳性率明显高于有远处转移者（OR=0.39,95%CI=0.22~0.70,P=0.001）;BECN1表达与胃癌患者性别、年龄、肿瘤浸润深度、淋巴结转移及TNM分期等无关（均P〉0.05）。结论：BECN1在胃癌的发生和胃癌细胞分化中可能起重要作用,且BECN1可能参与了胃癌细胞转移能力的调控。

Objective：To systematically analyze the expression of autophagy-related protein Beclin 1（BECN1） in gastric cancer tissue and the correlation between BECN1 expression and clinicopathologic features of gastric cancer patients.Methods：The studies investigating BECN1 expression in gastric cancer tissues and its clinical significance published up to February 2015 were collected by searching the national and international databases.After data extraction,a meta-analysis was performed by using RevMan 5.3 and Statal2.0 software.Results：Nine studies were finally included,involving 1 620 gastric cancer patients.The results of this metaanalysis showed that the positive expression rate of BECN1 in gastric cancer tissues was significantly lower than that in non-gastric cancer tissues（OR=0.11,95%CI=0.02-0.62,P=0.01）,in well differentiated gastric cancer tissues was significantly higher than that in moderately-poorly differentiated gastric cancer tissues（OR=14.30,95%CI=5.94-34.4,P=0.000）,and in gastric cancer tissues without distant metastasis was significantly higher than that in those with distant metastasis（OR=0.39,95%CI=0.22-0.70,P=0.001）,but no significant relationship was noted between BECN1 expression and gender,age,tumor infiltration depth,lymph node metastasis and TNM stage of gastric cancer patients（all P〉0.05）.Conclusion：BECNl may play a crucial role in gastric cancer carcinogenesis and differentiation of gastric cancer cells,and may also participate in the regulation of the metastasis ability of gastric cancer cells.