幽门螺杆菌感染与血浆中同型半胱氨酸的关系探讨

Study on relationship between helicobacter pylori infections and homocysteine

目的探讨健康体检人群幽门螺杆菌(Hp)感染与同型半胱氨酸(Hcy)的关系。方法选取2012年12月至2013年9月在该院体检中心接受健康体检的930例普通人群作为研究对象,采用免疫胶体金法测定Hp感染情况,根据Hp感染情况分为Hp阳性组(n=465)和Hp阴性组(n=465例),同时应用化学发光仪通过荧光偏振免疫检测法检测血浆总Hcy(tHcy),分析Hp感染与Hcy之间的关系。结果受检930例人群中,Hp阳性组tHcy水平高于阴性组(P>0.05);Hp阳性组tHcy水平升高的异常率68.39%,Hp阴性组tHcy水平升高的异常率44.30%,两组差异有统计学意义(P<0.05);Hp阳性组男性tHcy水平异常率88.25%,女性tHcy水平异常率18.80%;Hp阴性组男性Hcy水平异常率59.76%,女性Hcy水平异常率5.30%,组间同性别异常率及组内不同性别比较差异有统计学意义(P<0.05,P<0.01)。结论 Hp感染可能是导致高Hcy血症的危险因素之一,应积极开展Hp感染的防治,以减少心脑血管疾病的发生。

Objective To explore the relationship between helicobacter pylori infections and homocysteine （Hcy） in health checkup population. Methods A our hospital physical examination center during December 2012 to September 2013 were selected as the research object and were divided into Hp positive group （465 cases） and the negative group （465 cases） according to the Hp infection by the immune colloidal gold method. The level of Hcy was measured in two groups by fluorescence polarization immunoassay method. The relationship between helicobacter pylori infections and homoeysteine was analyzed. Results The abnormal rate of high serum level of Hcy in Hp positive group was 68.39 % ,While 44.30 μ m negative group, the difference was statistically significant （P〈0. 05）;the abnormal rate of male was 88.25%, female 18.80%;the abnormal rate of male was 59.76%, and that of female was 5. 30%. the difference of two groups had statistical significance （P〈 0.05, P〈 0.01）. Conclusion Hp infection may be a risk factor of high Hcy levels,and taking measures actively to prevent and control Hp infection may reduce the of the cardiovascular and cerebrovascular diseases.