鼻咽癌五野调强放射治疗方案的实现

Theintensity-modulated radiation therapy of five radiotherapy fields on nasopharyngeal carcinoma

目的在满足靶区及危及器官剂量要求的前提下,该研究以5个射野来进行调强放射治疗(IMRI)计划制订,从而达到以尽可能少的射野数目进行鼻咽癌的IMRI。方法通过对本院鼻咽癌患者放疗计划的对比分析,以0°、75°、125°、225°、285°方案进行布野,并以该布野方案同前五野、后五野、五野均分3种方案进行比较,对最终结果进行统计学分析。结果在靶区最大剂量(Dmax)和最小剂量(Dmin)上,4种布野方案差异无统计学意义(P>0.05);在靶区D95、平均剂量(Dmean)及危及器官的剂量上,4种布野方案差异有统计学意义(P<0.05)。结论综合比较4种布野方案在靶区、危及器官剂量分布,以0°、75°、125°、225°、285°方案布野时,能够得出更优的结果,该布野方案可实现本地区鼻咽癌患者的IMRI。

Objective Under the requirements of dose distribution in target and normal tissue,five radiotherapy fields are devoted to making Intensity-modulated radiation therapy （IMRT） plan, thus the IMRT radiotherapy of Nasopharyngeat Carcinoma （NPC） could be underway with the radiotherapy field as few as possible. Methods Through the comparison of the NPC patientsr IMRT plans in our hospital, the angle of fields have been make out with 0°, 75°, 125°, 225°and 285°. Atthe same time, this field scheme is compared with projects of front five fields.behind five fields and share five fields. The result was statisticatly analyzed. Results In these four field schemes,the maximum and minimum dose in the target area showed no statistically difference（P〈0. 05） ,while in the average dose,D95 and normal tissue dose have statistical difference（P〈（0.05）. Conclusion Comprehensive comparison of the dose distribution in the target and normal tissue in these four field schemes showed that the field scheme with the angles of 0°, 75°, 125°, 225°and 285°could obtain better results, so this field scheme should be more suitable for local area NPC patient＇ s IMRT.