骨痿膏方应用于骨质疏松性椎体骨折PKP术后的临床研究

Clinical Study of Guwei Paste Prescription for patients with Osteoporosis Vertebral Compression Fracture Postoperative PKP

目的:探讨中药骨痿膏方治疗骨质疏松性椎体骨折经皮椎体后凸成形术(Percutaneous Kypho Plasty,PKP)术后疼痛等疗效的临床研究。方法:将2014年1月至12月我院骨科门诊收治的骨质疏松性椎体骨折PKP术后的60例患者以1∶1比例按随机数字表法分为2组,其中对照组给予常规西药治疗,治疗组在对照组基础上加用骨痿膏方,疗程均为6个月。治疗结束后,比较2组患者疼痛、功能和骨密度变化的临床疗效,测定指标包括治疗前后的视觉模拟疼痛评分(VAS评分)、Oswestry功能障碍指数(ODI)、Cobb角及骨密度(BMP)变化。结果:研究结束后,治疗组患者在疼痛、功能等症状的改善方面均优于对照组,VAS评分、ODI和BMP2组比较差异有统计学意义。结论:骨痿膏方联合常规西药对于治疗骨质疏松性椎体骨折PKP术后的临床疗效可能优于单纯应用常规西药,建议在临床上推广使用。

Objective： To explore the clinical effect of treating osteoporosis vertebral compression fracture postoperative PKP（ percutaneous kypho plasty） with Guwei paste prescription. Methods： 60 cases of outpatients with osteoporosis vertebral compression fracture postoperative PKP in our hospital from January 2014 to December 2014 were randomly allocated into two groups with a 1∶ 1-ratio. Patients in the control group received conventional Western Medicine. Patients in the treatment group received Guwei paste prescription,besides the conventional Western Medicine. Measurements were performed after 180 ± 7 days treatment. The following data were collected： the change of bone mineral density（ BMP）,VAS and ODI before and after the treatment. Results： After the treatment,BMP,VAS and ODI were obviously higher than before,which was obviously higher than control group. Conclusion： Guwei paste prescription plus conventional Western Medicine maybe better than the same conventional Western Medicine alone for patients with osteoporosis vertebral compression fracture postoperative PKP. A widely clinical use could be recommended.