Box-Behnken响应面法优化宣木瓜药材、饮片一体化加工工艺

Optimization of Integrated Processing Technology for Medicinal Materials and Decoction Pieces of Chaenomeles speciosa by Box-Behnken Design and Response Surface Method

目的:建立和优化适宜的药材、饮片一体化加工工艺。方法:以齐墩果酸和熊果酸总量为指标,结合外观性状,单因素考察蒸制时间、干燥温度和干燥时间对宣木瓜饮片的影响,应用响应面法优化一体化加工工艺。结果:宣木瓜烫5 min后,再继续蒸4 min,切薄片,60℃干燥5 h为最佳工艺。结论:该工艺与传统饮片炮制工艺相比较,在保证饮片质量的同时,也降低了生产成本,提高了生产效率。

Objective：To establish and optimize the appropriate integrated processing technology of medicinal materials and decoction pieces of Chaenomeles Speciosa.Methods：The appearance character and content of oleanolic acid and ursolic acid were set as the study indicators to investigate the impact of the steaming time，drying temperaturer and drying time on Chaenomeles speciosa.The Box-Benhnken central composite design in the response surface analysis was adopted to optimize the preparation conditions.Results：The appropriate integrated processing technology was follows：the time of heating up in hot water was 5 minutes，the steaming time was 4 minutes，the drying temperature was 60 ℃，and the drying time was 5 hours.Conclusion：Compared with the traditional processing technology，the integrated processing technology ensures the drug quality，reduces the cost of production and improves production efficiency.