期刊文献+

房颤不同时期结构重构的血清学变化 被引量:7

The Serologic Changes of Structural Remodeling During Different Periods of Atrial Fibrillation
原文传递
导出
摘要 目的:探讨转化生长因子-β1(TGF-β1)、基质金属蛋白酶-9(MMP-9)、金属蛋白酶组织抑制因子-1(TIMP-1)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-10(IL-10)与阵发性或持续性房颤结构重构的关系。方法:入选患者分为3组,其中持续性房颤组30例、阵发性房颤组45例,以及32例阵发性室上速(包括预激综合征)作为对照组,通过ELISA方法检测上述患者左房血清的TGF-β1、MMP-9、TIMP-1、TNF-α、IL-6、IL-10水平,超声测量左心房长径。分析上述细胞因子水平与阵发性房颤或持续性房颤的关系。结果:阵发性房颤组与对照组相比,左房内径增大、TGF-β1、TNF-α升高(P<0.05),IL-10、TIMP-1降低(P<0.05),MMP-9无统计学差异。持续性房颤组与对照组相比,TGF-β1无统计学差异(P>0.05),MMP-9、TNF-α、IL-6均升高(P<0.05),IL-10、TIMP-1降低(P<0.05);阵发性房颤组TGF-β1高于持续性房颤组(P<0.05),持续性房颤组左房内径及MMP-9高于阵发性房颤组(P<0.05)。结论:阵发性房颤患者左房扩大,已出现结构重构,结构重构的血清学变化以TGF-β1升高为主;持续性房颤患者结构重构血清学变化以MMP-9、IL-6升高为主。 Objective: To investigate the relationship of TGF-β1, MMP-9, TIMP-1, TNF-α, IL-6, IL-10 with paroxysmal atrial fibrillation(AF) or persistent AF. Methods: The patients was divided into three groups, including 45 paroxysmal AF patients, 30 persistent AF patients and a control group of 32 paroxysmal suprawentricular tachycardia or WPW patients who underwent catheter ablation, Serum samples were respectively taken from left atrium of these patients and, the pre-ablation plasma concentrations of TGF-β1, MMP-9,TIMP-1, TNF-α, IL-6, IL-10 were evaluated by ELISA. The left atrial diameter(LAD) was detected by echocardiography. Results:Paroxysmal AF group compared with control group, the level of LAD, TGF-β1, TNF-α was increased(P〈0.05), the level of IL- 10 and TIMP- 1 was lower(P〈0.05), and MMP- 9 had no statistical difference(P〈0.05). Persistent AF group compared with control group, the level of TGF-β1 had no statistical difference(P〈0.05), the level of MMP- 9, TNF-α, IL- 6 was higher(P〈0.05), and IL- 10 and TIMP-1 was lower(P〈0.05). Comparison between paroxysmal AF group and persistent AF group, the levels of TGF-β1 in paroxysmal AF group was higher, LAD and the level of MMP- 9 was lower than that of persistent AF group(P〈0.05). Conclusions: Patients with paroxysmal AF already have structural remodeling, left atrial dilated, and the serum changes of structural remodeling are given priority to elevated TGF-β1, while the serum changes of structural remodeling in persistent AF are given priority to elevated MMP- 9 and IL- 6.
出处 《现代生物医学进展》 CAS 2015年第30期5864-5866,5934,共4页 Progress in Modern Biomedicine
基金 国家自然科学基金项目(81371709)
关键词 心房颤动 转化生长因子-Β1 基质金属蛋白酶-9 炎症 结构重构 Atrial fibrillation TGF-β1 MMP-9 Inflammation Structural remodeling
  • 相关文献

参考文献20

  • 1Sanfilippo AJ,Abascal VM,Sheehan M,et al.Atrial enlargement as a consequence of atrial fibrillation.A prospective echocardiographic study[J].Circulation,1990,82(3):792-797.
  • 2Frustaci A,Chimenti C,Bellocci F,et al.Histological substrate of atrial biopsies in patients with lone atrial fibrillation[J].Circulation,1997,96(4):1180-1184.
  • 3Antonios K,Irina S,Anatoli K,et al.Current concepts in the pathogenesis of atrial fibrillation[J].American Heart Journal,2009,15(7):243-252.
  • 4Suzuki T,Yamazaki T,Ogawa S,et ai.Echocardiographic predictors of frequency of paroxysmal atrial fibrillation (AF)and its progression to persistent AF in hypertensive patients with paroxysmal AF:Results from the Japanese Rhythm Management Trial II for Atrial Fibrillation (J-RHYTHM U Study)[J].Heart Rhythm,2011,8(12):1831-1836.
  • 5Lijnen PJ,Petrov W,Fagard RH.Induction of cardiac fibrosis by transforming growth factor-beta(l)[J].Mol Genet Metab,2000,71(6):418-435.
  • 6Kim SK,Park JH,Kim JY,et al.High plasma concentrations of transforming growth factor-p and tissue inhibitor of metalloproteinase-1-potential non-Invasive predictors for electroanatomical remodeling of atrium in patients with non-valvular atrial fibrillation[J].Circulation journal,2011,75(4):557-564.
  • 7Lin CS,Lai LP,Lin JL,et al.Increased expression of extracellular matrix proteins in rapid atrial pacing-induced atrial fibrillation[J].Heart Rhythm,2007,21(4):938-949.
  • 8Michael B,Ursula H,Siegfried L,et al.Transforming growth factor beta I (TGF-beta I)in atrial fibrillation and acute congestive heart failuie[J].Clin Res Cardiol,2010,92(10):248-254.
  • 9Tomita H,Egashira K,Ohara Y,et al.Early induction of transforminggrowth factor-beta via angiotensin II type I receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats[J].Hypertension,1998,32(8):273-279.
  • 10Nakajima H,Nakajima HO,Salcher O,et al.Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta (1)transgene in the heart[J].Circ Res,2000,86(9):571-579.

二级参考文献11

  • 1单鸿波,李悦,李为民.基质金属蛋白酶及其组织抑制因子与心房颤动心房结构重构的关系[J].中国心脏起搏与心电生理杂志,2007,21(2):170-172. 被引量:11
  • 2Nattel S. New ideas about atrial fibrillation 50 years on[J]. Nature, 2002, 415(6868) :219 -226.
  • 3Kim SK, Park JH, Kim JY, et al. High plasma concentrations of transforming growth factor-β and tissue inhibitor of metalloproteinase-1-potential non-Invasive predictors for electroanatomical remodeling of atrium in patients with non-valvular atrial fibrillation [ J ]. Circulation Journal, 2011,75(4):557-564.
  • 4Katoh Y, Nakazato Y. Can we predict electroanatomical remodeling of left atrium in patients with non-valvular atrial fibrillation by transforming growth factor-β and tissue inhibitor of metalloproteinase-1 ? [J]. Circulation journal, 2011,75(3):536-537.
  • 5Sivasubramanian N, Coker ML, Kurrelmeyer KM, et al. Left ventricular remodeling in transgenic mice with cardiac restricted overex- pression of tumor necrosis factor [ J ]. Circulation, 2001, 104 ( 7 ) : 826 - 831.
  • 6Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily[J]. Science, 2002, 296(5573 ) : 1646 - 1647.
  • 7Xiao H, Lei H, Qin S, et al. TGF-β1 expression and atrial myocardium fibrosis increase in atrial fibrillation secondary to rheumatic heart disease[J]. Clin Cardiol, 2010, 33(3) :149- 156.
  • 8Spach MS, Dolber PC. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age [ J ]. Circ Res, 1986, 58 ( 3 ) :356 -371.
  • 9Hayashi H, Wang C, Miyauchi Y, et al. Aging-related increase to inducible atrial fibrillation in the rat model [ J ]. J Cardiovasc Electrophysiol, 2002 , 13 ( 8 ) :801 - 808.
  • 10Platonov PG, Mitrofanova LB, Orshanskaya V, et al. Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age [ J ]. J Am Coil Cardiol, 2011, 58(21 ) :2225 -2232.

共引文献1

同被引文献54

引证文献7

二级引证文献46

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部