湘潭地区2013-2014年手足口病病原监测结果分析

Etiological Analysis of Hand-Foot-Mouth Disease

目的:分析2013-2014年湖南省湘潭市手足口病(HFMD)病原体型别及分布特征,为进一步完善HFMD的预防和治疗提供依据。方法:采用RT-PCR方法,对571例HFMD患儿进行肠道病毒通用型核酸(EV-RNA)、EV71及柯萨奇病毒A16(CA16)检测。结果:2013年除EV71及CA16外其他EV核酸阳性率75.30%,明显高于EV71的17.65%和CA16的7.05%(P<0.05),2014年EV71型核酸阳性率为50.68%,明显高于CA16的19.93%和其他EV的29.39%(P<0.05)。重症HFMD患儿EV71感染率明显高于轻症。结论:2013年湘潭地区HFMD患儿以除EV71及CA16外的其他EV病毒感染为主,2014年湘潭地区HFMD患儿以EV71感染为主。

Objective： To analyze the pathogenic type and the distribution characteristic of hand-foot-mouth disease（HFMD） in Xiangtan District of Hunan Province from 2013 to 2014 and to provide the reference for preventing and controlling HFMD. Methods：The EV-RNA, EV71 and Coxsackievirus A16（CA16） were detected by reverse transcription-polymerase chain reaction（RT-PCR） method in 571 children with HFMD. Result： In 2013, the positive rate（75.30%） of other EV except for EV71 and CA16 was significantly higher than that（17.65%） of EV71 and that（7.05%） of CA16（P〈0.05）. In 2014, the positive rate（50.68%） of EV71 was significantly higher than（19.93%） of CA16 and that（29.39%） of other EV（P〈0.05）. The positive rate of EV71 in sever HFMD children was higher than that in mild HFMD children. Conclusion： For HFMD children in Xiangtan district, the other EV except for EV71 and CA16 was the main pathogen type in 2013, while EV71 was the main pathogen type in 2014.